TAILIEUCHUNG - Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response

The Nbs1 protein associates with Mre11 and Rad50 proteins to form the Mre11–Rad50–Nbs1 complex, which plays an important role in the intracellular signaling pathway activated in response to DNA damage. Mutations in the genes for each of these three components of the Mre11– Rad50–Nbs1 complex result in human diseases characterized by genomic instability. | iFEBS Journal MINIREVIEW Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response Joo-Hyeon Lee and Dae-Sik Lim Department of BiologicalSciences Korea Advanced Institute of Science and Technology Guseong-D Yuseong-G Daejeon Korea Keywords ATM cell cycle checkpoint control DNA-damage response DNA repair intracellular signaling Nbs1 nuclear foci phosphorylation Correspondence . Lim Department of Biological Sciences Biomedical Research Center Korea Advanced Institute of Science and Technology 373-1 Guseoung-D Yuseong-G Daejeon 305-701 Korea Fax 82 42 8692610 Tel 82 42 8692635 E-mail daesiklim@ The Nbs1 protein associates with Mre11 and Rad50 proteins to form the Mre11-Rad50-Nbs1 complex which plays an important role in the intracellular signaling pathway activated in response to DNA damage. Mutations in the genes for each of these three components of the Mre11-Rad50-Nbs1 complex result in human diseases characterized by genomic instability. Insight into the functions of Nbs1 in the DNA damage response mediated by the protein kinase ataxia telangiectasia mutated has been provided by recent studies. Nbs1 acts both as a downstream target of ataxia telangiectasia mutated in the S-phase checkpoint of the cell cycle as well as an upstream modulator or activator of ataxia telangiectasia mutated in the DNA damage response. Received 12 December 2005 accepted 8 February 2006 doi Eukaryotic cells have evolved a signaling pathway that is activated by DNA damage. The primary function of this pathway is to sense DNA strand breaks and then to amplify the initial signal and convey it to downstream effectors that regulate cell cycle checkpoints and DNA repair 1 . Activation of the DNA damage signaling pathway by DNA double-strand breaks thus leads either to arrest of cell cycle progression and repair of the DNA breaks or if the damage is too extensive to death of the cell by apoptosis thus ensuring the .

• Báo cáo khoa học
• Report medicine
• traditional medicine
• scientific reports
• oxidation
• Crystal structure
• bacteria
• medical knowledge
• medical research
• analysis of cytoplasmic
• hemoglobin
• medicine
• cell proliferation
• breast cancer
• chemical reaction
• gastric cancer
• hormone medicine
• tumor cells
• biochemical studies
• environmental medicine