TAILIEUCHUNG - Báo cáo khoa học: Electrochemical biosensing with nanoparticles Arben Merkoci

This minireview looks at the latest trends in the use of nanoparticles (NPs) in electrochemical biosensing systems. It includes electrochemical characteri-zation of NPs for use as labels in affinity biosensors and other applications. DNA analysis involving NPs is one of the most important topics of current research in bionanotechnology. | ễFEBS Journal MINIREVIEW Electrochemical biosensing with nanoparticles Arben Merkoọi Institut Catala de Nanotecnologia and Universitat Autonoma de Barcelona Spain Keywords conductometric techniques DNA analysis differential pulse voltammetry electrochemical analysis gold nanoparticles labelling technologies nanotechnology protein analysis stripping voltammetry Correspondence A. Merkoci Institut Catala de Nanotecnologia Campus UAB 08193 Bellaterra Barcelona Catalonia Spain E-mail This minireview looks at the latest trends in the use of nanoparticles NPs in electrochemical biosensing systems. It includes electrochemical characterization of NPs for use as labels in affinity biosensors and other applications. DNA analysis involving NPs is one of the most important topics of current research in bionanotechnology. The advantages of the use of NPs in designing novel electrochemical sensors for DNA analysis are reviewed. Electrochemical NPs can also be used in designing immunoassays offering the possibility of easy low cost and simultaneous detection of several proteins. Research into NP applications in electrochemical analysis is in its infancy. Several aspects related to sensitivity as well integration of all the assay steps into a single one need to be improved. Received 26 September accepted 8 November 2006 doi Introduction Electrochemical sensing ES techniques are playing a growing part in various fields in which an accurate low cost fast and online measuring system is required. With regard to quality and cost ES is better than not only standard analytical methods assays but also sensors based on other transducing mechanisms. Beside the relatively low cost compared with optical instrumentation advantages such as the possibility of miniaturization as well as in-field applications make ES devices very attractive in several fields such as environmental monitoring food quality control and clinical analysis. The ES

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