TAILIEUCHUNG - Báo cáo khoa học: Steady-state kinetic behaviour of functioning-dependent structures

A fundamental problem in biochemistry is that of the nature of the coordination between and within metabolic and signalling pathways. It is conceivable that this coordination might be assured by what we term func-tioning-dependent structures (FDSs), namely those assemblies of proteins that associate with one another when performing tasks and that disassoci-ate when no longer performing them. | ỊFEBS Journal Steady-state kinetic behaviour of functioning-dependent structures Michel Thellier1 3 Guillaume Legent1 Patrick Amar2 3 Vic Norris1 3 and Camille Ripoll1 3 1 Laboratoire Assemblages moleculaires modelisation et imagerie SIMS Faculte des Sciences de l Universite de Rouen Mont-Saint-Aignan Cedex France 2 Laboratoire de recherche en informatique Universite de Paris Sud Orsay Cedex France 3 Epigenomics Project Genopole Evry France Keywords enzyme kinetics metabolic or signalling pathways mathematicalmodelling protein associations Correspondence M. Thellier Laboratoire Assemblages moleculaires modelisation et imagerie SIMS FRE CNRS 2829 Faculte des Sciences de l Universite de Rouen F-76821 Mont-Saint-Aignan Cedex France Fax 33 2 35 14 70 20 Tel 33 2 35 14 66 82 E-mail Received 12 January 2006 revised 26 June 2006 accepted 20 July 2006 doi A fundamental problem in biochemistry is that of the nature of the coordination between and within metabolic and signalling pathways. It is conceivable that this coordination might be assured by what we term functioning-dependent structures FDSs namely those assemblies of proteins that associate with one another when performing tasks and that disassociate when no longer performing them. To investigate a role in coordination for FDSs we have studied numerically the steady-state kinetics of a model system of two sequential monomeric enzymes E1 and E2. Our calculations show that such FDSs can display kinetic properties that the individual enzymes cannot. These include the full range of basic input output characteristics found in electronic circuits such as linearity invariance pulsing and switching. Hence FDSs can generate kinetics that might regulate and coordinate metabolism and signalling. Finally we suggest that the occurrence of terms representative of the assembly and disassembly of FDSs in the classical expression of the density of entropy production are .

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