TAILIEUCHUNG - Báo cáo khoa học: Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins Implications in mechanical stress-associated pathologies

Cells in various anatomical locations are constantly exposed to mechanical forces from shear, tensile and compressional forces. These forces are signifi-cantly exaggerated in a number of pathological conditions arising from various etiologies ., hypertension, obstruction and hemodynamic over-load. | ỊFEBS Journal REVIEW ARTICLE Mechanical regulation of the Cyr61 CCN1 and CTGF CCN2 proteins Implications in mechanical stress-associated pathologies Brahim Chaqour1 and Margarete Goppelt-Struebe2 1 Department of Anatomy and Cell Biology SUNY Downstate MedicalCenter Brooklyn NY USA 2 Department of Nephrology and Hypertension University Erlangen-Nuremberg Germany Keywords actin cytoskeleton bladder obstruction fibrosis hypertrophy mechanical overload mechanotransduction RhoA signaling shear stress smooth muscle cells Correspondence B. Chaqour Department of Anatomy and Cell Biology State University of New York MedicalCenter 450 Clarkson Avenue Box 5 Brooklyn NY 11203 USA Fax 1 718 0270 3732 Tel 1 718 270 8285 E-mail bchaqour@ M. Goppelt-Struebe Department of Nephrology and Hypertension University Erlangen-Nuremberg Loschgestrasse 8 91054 Erlangen Germany Fax 49 9i3i 8539202 Tel 49 9131 8539201 E-mail Goppelt-Struebe@rzmail. Received 10 April2006 revised 1 June 2006 accepted 6 June 2006 doi Cells in various anatomical locations are constantly exposed to mechanical forces from shear tensile and compressional forces. These forces are significantly exaggerated in a number of pathological conditions arising from various etiologies . hypertension obstruction and hemodynamic overload. Increasingly persuasive evidence suggests that altered mechanical signals induce local production of soluble factors that interfere with the physiologic properties of tissues and compromise normal functioning of organ systems. Two immediate early gene-encoded members of the family of the Cyr61 CTGF Nov proteins referred to as cysteine-rich protein 61 Cyr61 CCN1 and connective tissue growth factor CTGF CCN2 are highly expressed in several mechanical stress-related pathologies which result from either increased externally applied or internally generated forces by the actin cytoskeleton. Both Cyr61 and CTGF are structurally related .

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