TAILIEUCHUNG - Báo cáo khoa học: AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells

Adiponectin acts as an insulin-sensitizing adipokine that protects against obesity-linked metabolic disease, which is generally associated with endo-plasmic reticulum (ER) stress. The physiological effects of adiponectin on energy metabolism in the liver are mediated by its receptors. | AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells In-uk Koh1 2 Joo H. Lim1 Myung K. Joe1 Won H. Kim1 Myeong H. Jung3 Jong B. Yoon2 and Jihyun Song1 1 Division of Metabolic Disease Department of BiomedicalScience National institutes of Health Seoul South Korea 2 Department of Biochemistry College of Science Yonsei University Seodaemoon-Gu Seoul South Korea 3 Schoolof Korean Medicine Pusan National university Yangsan-si Gyeongnam South Korea Keywords AdipoR2 ATF3 ER stress insulin resistance obesity Correspondence M. H. Jung Schoolof Korean Medicine Pusan National university 30 Beom-eo ri Mulguem-eup Yangsan-si Gyeongnam 609-735 South Korea Fax 82 51 510 8437 Tel 82 51 510 8468 E-mail jung0603@ J. B. Yoon Department of Biochemistry College of Science Yonsei University 134 Shinchon-Dong Seodaemoon-Gu Seoul 120-749 South Korea Fax 82 2 392 3488 Tel 82 2 2123 2704 E-mail yoonj@ J. Song Division of Metabolic Disease Department of Biomedical Science National Institutes of Health 5 Nokbun-dong Eunpyung-gu Seoul 122-701 South Korea Fax 82 2 354 1057 Tel 82 2 380 1530 E-mail jhsong10@ Received 22 September 2009 revised 22 February 2010 accepted 9 March 2010 doi Adiponectin acts as an insulin-sensitizing adipokine that protects against obesity-linked metabolic disease which is generally associated with endoplasmic reticulum ER stress. The physiological effects of adiponectin on energy metabolism in the liver are mediated by its receptors. We found that the hepatic expression of adiponectin receptor 2 AdipoR2 was lower but the expression of markers of the ER stress pathway 78 kDa glucose-regulated protein GRP78 and activating transcription factor 3 ATF3 was higher in the liver of ob ob mice compared with control mice. To investigate the regulation of AdipoR2 by ER stress we added thapsigargin an ER stress inducer to a human hepatocyte cell line HepG2. Addition of .

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