TAILIEUCHUNG - Báo cáo y học: " Assessment of effectiveness measures in patients with schizophrenia initiated on risperidone longacting therapy: the SOURCE study results"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Assessment of effectiveness measures in patients with schizophrenia initiated on risperidone longacting therapy: the SOURCE study results | Macfadden et al. BMC Psychiatry 2011 11 167 http 1471-244X 11 167 BMC Psychiatry RESEARCH ARTICLE Open Access Assessment of effectiveness measures in patients with schizophrenia initiated on risperidone long-acting therapy the SOURCE study results 1 2 1 3 1 4 Wayne Macfadden Cherilyn DeSouza Concetta Crivera Chris M Kozma Riad D Dirani Lian Mao and Stephen C Rodriguez1 Abstract Background To evaluate effectiveness outcomes in a real-world setting in patients with schizophrenia initiating risperidone long-acting therapy RLAT . Methods This was a 24-month multicenter prospective longitudinal observational study in patients with schizophrenia who were initiated on RLAT. Physicians could change treatment during the study as clinically warranted. Data were collected at baseline and subsequently every 3 months up to 24 months. Effectiveness outcomes included changes in illness severity as measured by Clinical Global Impression-Severity CGI-S scale functional scores as measured by Personal and Social Performance PSP scale Global Assessment of Functioning GAF and Strauss-Carpenter Levels of Functioning LOF and health status Medical Outcomes Survey Short Form-36 SF-36 . Life-table methodology was used to estimate the cumulative probability of relapse over time. Adverse events were evaluated for safety. Results 532 patients were enrolled in the study 209 completed the 24-month study and 305 had at least 12 months of follow-up data. The mean SD age of patients was years. Most patients were male and either Caucasian or African American . All changes in CGI-S from baseline at each subsequent 3-month follow-up visit were statistically significant p .0001 indicating improvement in disease severity. Improvements were also noted for the PSP GAF and total LOF indicating improvement in daily functioning and health outcome. Conclusions Patients with schizophrenia who were initiated on RLAT demonstrated improvements in measures .

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