TAILIEUCHUNG - Báo cáo khoa học: G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis

Akt (also known as protein kinase B) plays an integral role in many intra-cellular signaling pathways activated by a diverse array of extracellular sig-nals that target several different classes of membrane-bound receptors. Akt plays a particularly prominent part in signaling networks that result in the modulation of cellular proliferation, apoptosis and survival. | ỊFEBS Journal REVIEW ARTICLE G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis David C. New Kelvin Wu Alice W. S. Kwok and Yung H. Wong Department of Biochemistry the Molecular Neuroscience Center and the Biotechnology Research Institute Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China Keywords Akt protein kinase B G protein G protein-coupled receptor cell cycle apoptosis Correspondence Y. H. Wong Department of Biochemistry Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China Fax 852 2358 1552 Tel 852 2358 7328 E-mail boyung@ Received 17 August 2007 revised 17 September 2007 accepted 24 September 2007 doi Akt also known as protein kinase B plays an integral role in many intracellular signaling pathways activated by a diverse array of extracellular signals that target several different classes of membrane-bound receptors. Akt plays a particularly prominent part in signaling networks that result in the modulation of cellular proliferation apoptosis and survival. Thus the overexpression of Akt subtypes has been measured in a number of cancer types and dominant-negative forms of Akt can trigger apoptosis and reduce the survival of cancer cells. G protein-coupled receptors act as cell-surface detectors for a diverse spectrum of biological signals and are able to activate or inhibit Akt via several direct and indirect means. In this review we shall document how G protein-coupled receptors are able to control Akt activity and examine the resulting biochemical and physiological changes with particular emphasis on cellular proliferation apoptosis and survival. Akt also known as protein kinase B PKB is a ser-ine threonine protein kinase that plays a pivotal role in many physiological processes including metabolism development cell cycle progression migration and survival 1-4 . The Akt subfamily of protein kinases consists of .

• Báo cáo khoa học
• Report medicine
• traditional medicine
• scientific reports
• medical knowledge
• cytoplasm
• analysis of cytoplasmic
• medical research
• oxidation
• Crystal structure
• bacteria
• hemoglobin
• medicine
• cell proliferation
• breast cancer
• chemical reaction
• gastric cancer
• hormone medicine
• tumor cells
• biochemical studies
• environmental medicine