TAILIEUCHUNG - A pathway that links reproductive status to lifespan in Caenorhabditis elegans

In several countries, Pathfinder has successfully enhanced access, knowledge, and cultural acceptance of reproductive health by training and supporting Community Health Workers (CHWs). CHWs (known by various other names throughout the world) are members of the community in which they work, and are selected by the community and community leaders, Pathfinder’s partner organizations, or Pathfinder itself to work as health volunteers. Their duties vary depending on the country, project, and local needs. But at a minimum, after a training of two to three weeks, CHWs have a basic understanding of male and female reproductive anatomy, how different contraceptive methods work, know when to refer clients for. | Ann. Acad. Sci. ISSN 0077-8923 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Issue Reproductive Aging A pathway that links reproductive status to lifespan in Caenorhabditis elegans Cynthia Kenyon Department of Biochemistry and Biophysics University of California San Francisco California Address for correspondence Cynthia Kenyon Mission Bay Genentech Hall MC2200 600 16th Street Room S312A San Francisco California 94158-2517. In the nematode Caenorhabditis elegans and the fruit fly Drosophila loss of the germline stem cells activates lifespanextending FOXO-family transcription factors in somatic tissues and extends lifespan suggesting the existence of an evolutionarily conserved pathway that links reproductive state and aging. Consistent with this idea reproductive tissues have been shown to influence the lifespans of mice and humans as well. In C. elegans loss of the germ cells activates a pathway that triggers nuclear localization of the FOXO transcription factor DAF-16 in endodermal tissue. DAF-16 then acts in the endoderm to activate downstream lifespan-extending genes. DAF-16 is also required for inhibition of insulin insulin-like growth factor 1 IGF-1 signaling to extend lifespan. However the mechanisms by which inhibition of insulin IGF-1 signaling and germline loss activate DAF-16 FOXO are distinct. As loss of the germ cells further doubles the already-long lifespan of insulin IGF-1 pathway mutants a better understanding of this reproductive longevity pathway could potentially suggest powerful ways to increase healthy lifespan in humans. Keywords germ cells DAF-12 nuclear hormone receptor aging The aging process touches everyone s life and as a scientific problem it is fascinating in its own right. What determines the rate at which we age Aging was once thought to just happen. We wear out like old shoes. Yet the aging process is not completely random and stochastic. Different species can have dramatically different lifespans and even

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