TAILIEUCHUNG - Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia

Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia Tanja Johannes1,2, Egbert G Mik1, Boris Nohé2, Nicolaas JH Raat1, Klaus E Unertl2 and Can Ince1 1Department 2Department of Physiology, Academic Medical Center, University of Amsterdam, The Netherlands of Anesthesiology and Critical Care, University Hospital Tuebingen, Germany Corresponding author: Tanja Johannes, Received: 28 Feb 2006 Revisions requested: 18 Apr 2006 Revisions received: 23 Apr 2006 Accepted: 12 May 2006 Published: 19 Jun 2006 Critical Care 2006, 10:R88 (doi:) This article is online at: © 2006 Johannes et al.; licensee BioMed Central Ltd. This is an open access. | Available online http content 10 3 R88 Research Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia Tanja Johannes1 2 Egbert G Mik1 Boris Nohé2 Nicolaas JH Raat1 Klaus E Unertl2 and Can Ince1 Department of Physiology Academic Medical Center University of Amsterdam The Netherlands 2Department of Anesthesiology and Critical Care University Hospital Tuebingen Germany Corresponding author Tanja Johannes Received 28 Feb 2006 Revisions requested 18 Apr 2006 Revisions received 23 Apr 2006 Accepted 1 2 May 2006 Published 19 Jun 2006 Critical Care 2006 10 R88 doi cc4948 This article is online at http content 10 3 R88 2006 Johannes et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Septic renal failure is often seen in the intensive care unit but its pathogenesis is only partly understood. This study performed in a normotensive rat model of endotoxemia tests the hypotheses that endotoxemia impairs renal microvascular PO2 pPO2 and oxygen consumption VO2ren that endotoxemia is associated with a diminished kidney function that fluid resuscitation can restore pPO2 VO2ren and kidney function and that colloids are more effective than crystalloids. Methods Male Wistar rats received a one-hour intravenous infusion of lipopolysaccharide followed by resuscitation with HES130 Voluven HES200 HeS-STERIL 6 or Ringer s lactate. The renal pPO2 in the cortex and medulla and the renal venous PO2 were measured by a recently published phosphorescence lifetime technique. Results Endotoxemia induced a reduction in renal blood flow and anuria while the renal pPO2 and VO2 ren remained relatively unchanged. .

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