TAILIEUCHUNG - Báo cáo sinh học: "Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyll"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyll. | Mansour et al. Annals of Clinical Microbiology and Antimicrobials 2011 10 32 http content 10 1 32 ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS RESEARCH Open Access Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyllum 1 X 1 1 1 1 Hedi Ben Mansour Sonia Yatouji Sihem Mbarek Ikram Houas Afef Delai and Dorra Dridi Abstract For centuries plants have been used in traditional medicines and there has been recent interest in the chemopreventive properties of compounds derived from plants. In the present study we investigated the antibutyrylcholinestrasic anti-BuChE and antioxidant against some free radicals activities of extracts from Rhus pentaphyllum. Aqueous extracts were prepared from powdered R. pentaphyllum roots leaves and seeds and characterized for the presence of tannins flavonoids and coumarins. Seeds aqueous extract contained the highest quantities of both flavonoids and tannins and respectively . In the same way seeds extracts displayed remarkable inhibition against BuChE over 95 at 100 pg ml and with IC50 gg ml. In addition compared to leaves and roots extracts seeds aqueous extract revealed relatively strong antiradical activity towards the ABTS IC50 gg ml and DPPH IC50 gg ml free radicals and decreased significantly the reactive oxygen species such O2- IC50 gg ml formation evaluated by the non-enzymatic generating O2- system Nitroblue tetrazolium riboflavine . These data suggest that the anti-BuChE activities mechanism of these extracts occurs through a free radical scavenging capacities. The present study indicates that extracts of Rhus pentaphyllum leaves seeds and roots are a significant source of compounds such as tannins flavonoids and coumarins with anti-BuChE and antioxidant activities and thus may be useful for chemoprevention. Keywords Rhus pentaphyllum anti-Butyrylcholinesterasic activity free radical scavenging

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