TAILIEUCHUNG - Báo cáo khoa hoc : Alteration of the N-glycome of bovine milk glycoproteins during early lactation

Milk provides nutritional, immunological and developmental components for newborns. Whereas identification of such components has been per-formed by targeting proteins and free oligosaccharides, structural and func-tional analyses of the N-glycome of milk glycoproteins are scarce. | IFEBS Journal Alteration of the N-glycome of bovine milk glycoproteins during early lactation Shota Takimori1 Hideyuki Shimaoka2 Jun-Ichi Furukawa1 Tadashi Yamashita3 Maho Amano1 Naoki Fujitani4 Yasuhiro Takegawa4 Lennart Hammarstrom5 Imre Kacskovics6 Yasuro Shinohara4 and Shin-Ichiro Nishimura1 1 Laboratory of Advanced ChemicalBiology Graduate Schoolof Advanced Life Science Hokkaido University Japan 2 Sumitomo Bakelite Co. Ltd Tokyo Japan 3 Laboratory of Embryonic and Genetic Engineering Graduate Schoolof Advanced Life Science Hokkaido University Japan 4 Laboratory of Medicaland FunctionalGlycomics Graduate Schoolof Advanced Life Science Hokkaido University Japan 5 Division of ClinicalImmunology Karolinska Institutet Huddinge Sweden 6 Department of Immunology Institute of Biology Faculty of Science Eotvos Lorand University Budapest Hungary Keywords bovine milk glycoproteins colostrum FcRn glycomics IgG Correspondence Y. Shinohara N21 W11 Kita-ku Sapporo 001-0021 Japan Fax 81 11 706 9087 Tel 81 11 706 9091 E-mail yshinohara@ I. Kacskovics Department of Immunology Institute of Biology Faculty of Science Eotvos Lorand University Pazmany Peter s. 1 C 1117 Budapest Hungary Fax 36 1 381 2176 Tel 36 1 381 2175 E-mail ikacsko@ . Nishimura Laboratory of Advanced ChemicalBiology Graduate Schoolof Advanced Life Science Hokkaido University Sapporo 001-0021 Japan Fax 81 11 706 9042 Tel 81 11 706 9043 E-mail shin@ Received 12 May 2011 revised 7 July 2011 accepted 8 August 2011 doi Milk provides nutritional immunological and developmental components for newborns. Whereas identification of such components has been performed by targeting proteins and free oligosaccharides structural and functional analyses of the N-glycome of milk glycoproteins are scarce. In this study we investigated for the first time the alterations of the bovine milk N-glycome during early lactation 1 day 1 2 3 and 4 weeks .

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