TAILIEUCHUNG - CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection

Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and. | Andersen et al. BMC Infectious Diseases 2012 12 66 http 1471-2334 12 66 BMC Infectious Diseases RESEARCH ARTICLE Open Access CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection 1 2 3 3 3 Aase B Andersen Nyagosya S Range John Changalucha George PrayGod Jeremiah Kidola Daniel Faurholt-Jepsen4 Henrik Krarup5 Harleen MS Grewal6 and Henrik Friis4 Abstract Background The interaction of HIV and tuberculosis TB on CD4 levels over time is complex and has been divergently reported. Methods CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area. Results Of 1 605 study participants 1 250 were PTB patients and 355 were non-TB controls. At baseline HIV was associated with 246 95 CI 203 279 cells per pL lower CD4 counts. All PTB patients had 100 cells per pL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment whereas those prescribed ART between baseline and 2 months and between 2 and 5 months increased by 69 22 117 and 110 52 168 CD4 cells per pL after 5 months. Conclusions The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment. Trial registration number Clinical NCT00311298 Keywords Pulmonary tuberculosis HIV CD4 cells TB treatment Background The total number of circulating CD4 cells in HIV infected patients have in large patient series been acknowledged as the strongest single predictive factor of clinical deterioration 1-3 .

• Y học thường thức
• Abiotic Stress
• SRO Family
• Characterization
• Plant Antioxidative
• Heavy Metal Toxicity
• Genetic and Molecular
• A constraint in farming
• Heat stress
• Water logging
• Mneral toxicity
• Mutualistic Symbio tic
• Crop plants
• Abiotic stress management of crop plants
• Plant Endophyte interaction
• Molecular breeding
• Anthesis SilkingInterval
• Abiotic stress (Drought) tolerance in maize
• Recent advances in breeding
• Biotic and abiotic stress
• Genetic improvement of wheat
• Genetic improvement
• Wheat for biotic
• Abiotic stress tolerance
• High temperature
• Cellular changes
• Impact of abiotic stress
• Plant growth
• Crop production
• Abiotic stress tolerance in legumes
• Critical approaches
• Global climate changes
• Food production presently exacerbated
• Compatible solute
• Epigenetic modification
• Cross talk
• Seed germination
• Stress tolerance
• BMC Plant Biology
• Endoplasmic reticulum
• Biotic stress
• Plant physiology
• Ferritin lacking mutant
• Triticum aestivum L
• A brassicae
• Cytosolic calcium elevation
• Plant Biology
• Creeping bentgrass
• Small heat shock protein
• Especially heat stress
• Tamarix hispida
• Turkish Journal of Botany
• Tạp chí Thực vật học
• Gene expression
• Posttranslational modification
• Small molecules
• Stress combinations
• Water status
• Vitis vinifera
• Abiotic biotic stress
• Manage Abiotic Stress
• Genetic Diversity
• Characterisation
• Plant Responses
• Abiotic Stresses
• Importance of Genetic
• Dryland Regions
• Trehalose and Abiotic
• Biological Systems
• Glyoxalase System
• Organic farming
• Biotic and abiotic stress tolerance
• Solanaceous vegetables
• Alternate tool for biotic
• Abiotic tolerance
• Improved growth and production
• Rubisco and abiotic stresses in plants
• 1 5 bisphosphate carboxylase/oxygenase
• Photo respiratory carbon oxidation
• ATP dependent manner
• Chlorophyll
• Salinity Stress
• Salt Tolerance
• Harvested Fruits
• Fruits and Vegetables
• Moisture stress
• Salinity management
• Cereals and pulses
• Amelioration in cereals
• Genetics and Adaptation
• Plant Genes
• Diagnosis