TAILIEUCHUNG - Deficiency of Micronutrient Status in Pulmonary Tuberculosis Patients in North India

The results was read according to the grading system of the International Union Against TB and Lung Diseases as - , +, ++, +++7. Thereafter, the sputum was decontaminated using 4 per cent NaOH. The resulting solution was mixed using vortex mixer. About one ml from the mixture was inoculated onto prepared modified Ogawa egg medium as previously demonstrated8 and incubated at 37oC for six weeks. M. tuberculosis strain H37Rv and sterile Ogawa medium were used as positive and negative controls respectively. Contamination on Ogawa medium was determined by looking for growth before two weeks of incubation and by carrying out Z-N reaction and standard biochemical tests9. Subjects from whom AFB positive samples. | Biomedical Research 2011 22 4 449-454 Deficiency of Micronutrient Status in Pulmonary Tuberculosis Patients in North India Irfan Ahmad VK Srivastava R Prasad Mohd. Yusuf Safia M Saleem Wahid Ali Department of Hospital Administration CSM Medical University UP Lucknow India Department of Pulmonary Medicine CSM Medical University UP Lucknow India Department of Pathology CSM Medical University UP Lucknow India Abstract Malnutrition is observed frequently in patients with pulmonary tuberculosis TB but their micronutrient status especially of Vitamin A and Zinc is still poorly documented. The objective of this study was to investigate the micronutrient status of patients with active pulmonary tuberculosis admitted in the Department of Pulmonary Medicine CSM Medical University UP Lucknow. In this case-control study 43 patients aged 18-55 year with active pulmonary TB were enrolled and blood sample was taken. Cases had clinical and radiographic abnormalities consistent with pulmonary TB and at least two sputum specimens showing acid-fast bacilli. Micronutrient status data were collected. Compared with healthy control cases TB patients had significantly lower concentrations of blood haemoglobin WBC count serum albumin serum retinol and zinc whereas the concentration of free erythrocyte zinc protoporphyrin concentration was greater. In conclusion the micronutrient status of patients with active pulmonary TB was poor compared with healthy subjects. Low concentrations of haemoglobin and of serum retinol and zinc were more pronounced in malnourished TB patients. Key Words Malnutrition Micronutrient Tuberculosis Vitamin A Zinc. Accepted June 27 2011 Introduction India is tuberculosis burden country of the world. Tuberculosis is a major barrier to social and economic development and it is one of the most important causes of death in developing countries. Vitamin A deficiency has been found to be associated with many infectious diseases. A high prevalence of vitamin A deficiency .

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