TAILIEUCHUNG - báo cáo khoa hoc : The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus

The Rhodopsin family of G protein coupled receptors (GPCRs) includes the phylogenetic a-group consisting of about 100 human members. The a-group is the only group of GPCRs that has many receptors for biogenic amines which are major drug targets. Several members of this group are orphan receptors and their functions are elusive. In this study we present a detailed phylogenetic and anatomical characterization of the Gpr153 recep-tor and also attempt to study its functional role. | IFEBS Journal The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus cerebellum and the arcuate nucleus Qmitha Qroodharan AlrriArt1 x olorio p C arlini1 2 Ta iana I lai ina1 filna Qtonhanccr n1 UMIL uiccdidH ar I us o. 11 lei I aieria . all I aljai la aiuiia ga u tcpdHooUH Wolfgang H. Sommer3 Markus Heilig4 Susana R. de Barioglio2 Robert Fredriksson1 and Helgi B. Schioth1 1 Department of Neuroscience FunctionalPharmacology Uppsala University Sweden 2 Departamento de Farmacologia Universidad Nacionalde Cordoba Argentina 3 Department of Psychopharmacology Central institute of MentalHealth Mannheim Germany 4 Laboratory of Clinicaland TranslationalStudies National institute on AlcoholAbuse and Alcoholism National institutes of Health Bethesda MD USA Keywords anxiety decision making GPCR Gpr153 Gpr162 Correspondence H. B. Schioth Department of Neuroscience BiomedicalCenter Box 593 SE 75124 Uppsala Sweden Fax 46 18 51 15 40 Tel 46 18 471 4160 E-mail helgis@ Received 6 May 2011 revised 28 September 2011 accepted 3 October 2011 doi The Rhodopsin family of G protein coupled receptors GPCRs includes the phylogenetic a-group consisting of about 100 human members. The a-group is the only group of GPCRs that has many receptors for biogenic amines which are major drug targets. Several members of this group are orphan receptors and their functions are elusive. In this study we present a detailed phylogenetic and anatomical characterization of the Gpr153 receptor and also attempt to study its functional role. We identified the homologue of Gpr153 in the elephant shark genome and phylogenetic and synteny analyses revealed that Gpr162 and Gpr153 share a common ancestor that split most likely through a duplication event before the divergence of the tetrapods and the teleost lineage. A quantitative real-time PCR study reveals widespread expression of

• Báo cáo khoa học
• Scientific reports
• scientific research
• biochemistry
• arcuate nucleus
• cerebellum
• hormone medicine
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes