TAILIEUCHUNG - báo cáo khoa hoc : Inhibition of autophagy may suppress the development of hepatoblastoma

Hepatoblastoma (HB) is a rare cancer but represents the most common liver malignancy in children under 3 years of age. Nevertheless, a clear understanding of the pathogenesis is lacking. Although the treatment of HB has been dramatically improved by combining chemotherapy regimens with surgery | IFEBS Journal Inhibition of autophagy may suppress the development of hepatoblastoma Yanxin Chang1 2 Lei Chen1 Yuan Liu1 Liang Hu1 Liang Li1 Qianqian Tu1 2 Ruoyu Wang1 2 Mengchao Wu2 Jiahe Yang2 and Hongyang Wang1 2 3 1 InternationalCo-operation Laboratory on SignalTransduction Eastern Hepatobiliary Surgery Institute Second Military MedicalUniversity Shanghai China 2 Department of Surgery Eastern Hepatobiliary Surgery Hospital Second Military MedicalUniversity Shanghai China 3 State Key Laboratory for Oncogenes and Related Genes Cancer Institute of Ren Ji Hospital Shanghai Jiao Tong University Shanghai China Keywords apoptosis ATG5 autophagy BECN1 hepatoblastoma Correspondence H. Wang InternationalCo-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Institute Second Military MedicalUniversity Shanghai 200438 China Fax 86 21 65566851 Tel 86 21 81875361 E-mail hywangk@ J. Yang Department of Surgery Eastern Hepatobiliary Surgery Hospital Second Military MedicalUniversity Shanghai 200438 China Fax 86 21 65566851 Tel 86 21 81875261 E-mail ehbhjhyang@ These authors contributed equally to this work Hepatoblastoma HB is a rare cancer but represents the most common liver malignancy in children under 3 years of age. Nevertheless a clear understanding of the pathogenesis is lacking. Although the treatment of HB has been dramatically improved by combining chemotherapy regimens with surgery its fatal outcome of fast development and recurrence makes new treatment strategies for HB based on an improved understanding of the pathogenesis essential. Autophagy is believed to be important in the progression of cancers. However the role of autophagy in HB remains to be elucidated. Here we show that autophagy is activated in HB tissues and cells under the conditions of starvation or chemotherapy coupled with the over-expression of autophagic-related genes BECN1 and ATG5. Suppression of autophagy with pharmacological agents and small interfering

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