TAILIEUCHUNG - Báo cáo y học: "Definition of disease states in early arthritis: remission versus minimal disease activity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Definition of disease states in early arthritis: remission versus minimal disease activity. | Available online http content 8 4 216 Review Aspects of early arthritis Definition of disease states in early arthritis remission versus minimal disease activity Annette HM van der Helm-van Mil Ferdinand C Breedveld and Tom WJ Huizinga Department of Rheumatology Leiden University Medical Center The Netherlands Corresponding author Tom WJ Huizinga Published 3 July 2006 This article is online at http content 8 4 216 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 216 doi ar1983 Abstract With regard to rheumatoid arthritis remission as currently used in the literature can have two meanings either a state with persistent absence of clinical and radiological signs of disease activity without being treated for a specific time period or it may point to a disease state with minimal disease activity during antirheumatic treatment. A risk factor for the first is absence of autoantibodies with the anti-CCP-antibodies as best predictors whereas risk factors for achieving a drug-induced state of minimal disease activity are not well defined. These definitions of remission refer to different disease states therefore we propose that the term remission is reserved for patients that are not treated with antirheumatic drugs. Introduction Since it was first named by Sir AB Garrod in his treatise of 1859 1 rheumatoid arthritis RA has been considered a chronic disease which implies that the curing of it or longstanding remission from it is an uncommon course of the disease. Although remission has always been the ultimate goal of treatment during the times of the pyramid treatment strategy the prevalence of remission was low and the main effect of therapy was to slow the progression of the disease. The observation that even patients with low disease activity exhibit an increase in disability as well as radiographic progression has prompted the rheumatological community to perform trials that have .