TAILIEUCHUNG - Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity. | Available online http content 7 6 R1338 Research article Reduced transforming growth factor-beta signaling in cartilage of old mice role in impaired repair capacity EN Blaney Davidson A Scharstuhl EL Vitters PM van der Kraan and WB van den Berg Experimental Rheumatology and Advanced Therapeutics St Radboud University Medical Centre Nijmegen Geert Grooteplein 26 6525 GA Nijmegen The Netherlands Corresponding author PM van der Kraan Received 4 Jul 2005 Revisions requested 26 Jul 2005 Revisions received 18 Aug 2005 Accepted 1 Sep 2005 Published 30 Sep 2005 Arthritis Research Therapy 2005 7 R1338-R1347 DOI ar1833 This article is online at http content 7 6 R1338 2005 Blaney Davidson et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Osteoarthritis OA is a common joint disease mainly effecting the elderly population. The cause of OA seems to be an imbalance in catabolic and anabolic factors that develops with age. IL-1 is a catabolic factor known to induce cartilage damage and transforming growth factor TGF -beta is an anabolic factor that can counteract many IL-1-induced effects. In old mice we observed reduced responsiveness to TGF-beta-induced IL-1 counteraction. We investigated whether expression of TGF-beta and its signaling molecules altered with age. To mimic the TGF-beta deprived conditions in aged mice we assessed the functional consequence of TGF-beta blocking. We isolated knee joints of mice aged 5 months or 2 years half of which were exposed to IL-1 by intra-articular injection 24 h prior to knee joint isolation. Immunohistochemistry was performed staining for TGF-beta1 -2 or -3 TGF-betaRl or -RII Smad2 -3 -4 -6

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