TAILIEUCHUNG - Genetic copy number variants in sib pairs both affected with schizophrenia

Schizophrenia is a complex disorder with involvement of multiple genes. Methods: In this study, genome-wide screening for DNA copy-number variations (CNVs) was conducted for ten pairs, a total of 20 cases, of affected siblings using oligonucleotide array-based CGH. Results: We found negative symptoms were significantly more severe (p | NSC Lee et al. Journal of Biomedical Science 2010 17 2 http content 17 1 2 The cost of publication in Journal of Biomedical Science is bourne by the National Science Council Taiwan. JOURNAL OF BIOMEDICAL SCIENCE RESEARCH Open Access Genetic copy number variants in sib pairs both affected with schizophrenia Chia-Huei Lee41 Chih-Min Liut2 Chun-Chiang Wen 2 Shun-Min Chang1 and Hai-Gwo Hwu 2 3 4 Abstract Background Schizophrenia is a complex disorder with involvement of multiple genes. Methods In this study genome-wide screening for DNA copy-number variations CNVs was conducted for ten pairs a total of 20 cases of affected siblings using oligonucleotide array-based CGH. Results We found negative symptoms were significantly more severe p in the subgroup that harbored more genetic imbalance n 13 n number of CNV-disrupted genes as compared with the subgroup with fewer CNVs n 6 indicating that the degree of genetic imbalance may influence the severity of the negative symptoms of schizophrenia. Four central nervous system CNS related genes including CCAAT enhancer binding protein delta CEBPD retinoid X receptor alpha RXRA LIM homeobox protein 5 LHX5 and serine threonine kinase 11 STK11 are recurrently incidence disrupted by CNVs. Two genes PVR poliovirus receptor and BU678720 are concordantly deleted in one and two respectively pairs of co-affected siblings. However we did not find a significant association of this BU678720 deletion and schizophrenia in a large case-control sample. Conclusions We conclude that the high genetic loading of CNVs may be the underlying cause of negative symptoms of schizophrenia and the CNS-related genes revealed by this study warrant further investigation. Background Schizophrenia is a devastating mental disorder and its etiology has yet to be fully elucidated. Genetic epidemiological studies have shown that schizophrenia is predominantly genetically determined and has a high .

TAILIEUCHUNG - Chia sẻ tài liệu không giới hạn
Địa chỉ : 444 Hoang Hoa Tham, Hanoi, Viet Nam
Website : tailieuchung.com
Email : tailieuchung20@gmail.com
Tailieuchung.com là thư viện tài liệu trực tuyến, nơi chia sẽ trao đổi hàng triệu tài liệu như luận văn đồ án, sách, giáo trình, đề thi.
Chúng tôi không chịu trách nhiệm liên quan đến các vấn đề bản quyền nội dung tài liệu được thành viên tự nguyện đăng tải lên, nếu phát hiện thấy tài liệu xấu hoặc tài liệu có bản quyền xin hãy email cho chúng tôi.
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.