TAILIEUCHUNG - THROMBOPHILI

What is thrombophilia? Thrombophilia is a condition where the blood forms clots more easily than normal, which can lead to unwanted blood clots in the body. There are different kinds of thrombophilia. What causes thrombophilia? Thrombophilia occurs if the normal balance of the clotting system is upset. There may be too much of a clotting factor, or too little of a factor that opposes clotting. Congenital Common types; most common causes are hyperactivity of procoagulants or type II,[9] which are more severe than type I: • Factor V Leiden • Prothrombin mutation • High homocysteine levels due to MTHFR. | THROMBOPHILIA What is thrombophilia Thrombophilia is a condition where the blood forms clots more easily than normal which can lead to unwanted blood clots in the body. There are different kinds of thrombophilia. What causes thrombophilia Thrombophilia occurs if the normal balance of the clotting system is upset. There may be too much of a clotting factor or too little of a factor that opposes clotting. Congenital Common types most common causes are hyperactivity of procoagulants or type II 9 which are more severe than type I Factor V Leiden Prothrombin mutation High homocysteine levels due to MTHFR mutation or vitamin deficiency vitamins B6 B12 and folic acid . Sickle-cell disease only small risk Rare forms most being deficiency of anticoagulants or type I less severe Antithrombin III deficiency. Protein C deficiency. Protein S deficiency. Plasminogen and fibrinolysis disorders very rare Acquired Causes posing high risk for thrombosis Antiphospholipid antibodies anti-cardiolipin antibodies and or lupus anticoagulants Heparin-induced thrombocytopenia Paroxysmal nocturnal hemoglobinuria Lower risk for thrombosis Nephrotic syndrome Hyperestrogenemia Estrogen-containing hormonal contraceptives Tobacco smoking What are the symptoms of thrombophilia There are two types of blood clots clots in arteries and clots in veins. Clots in veins are the most common type with thrombophilia - this is called a venous thrombosis . Possible symptoms are Pain and swelling in a leg. This occurs if you have a blood clot in a large vein in a leg. This is commonly known as a deep vein thrombosis or DVT . The clot may travel to the heart and on into a lung causing a pulmonary embolus or PE . Possible symptoms are chest pain pain on deep breathing shortness of breath or rarely collapse. Some types of thrombophilia can cause clots in unusual sites such as the brain gut or liver. This can cause symptoms in the head or the abdomen tummy . Clots in liver veins are called Budd-Chiari syndrome . .

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