TAILIEUCHUNG - Báo cáo sinh học: "Computing approximate monogenic model likelihoods in large pedigrees with loops"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Computing approximate monogenic model likelihoods in large pedigrees with loops | Genet Sei Evol 1995 27 567-579 Elsevier INRA 567 Original article Computing approximate monogenic model likelihoods in large pedigrees with loops LLG Janss JAM Van Arendonk JHJ Van der Werf Wageningen Agricultural University Department of Animal Breeding PO Box 338 6700 AH Wageningen The Netherlands Received 30 January 1995 accepted 11 September 1995 Summary - In this study iterative peeling is introduced a method equivalent to the traditional recursive peeling method for computing exact likelihoods in nonlooped pedigrees but which can also be used to obtain approximate likelihoods in looped pedigrees. Iterative peeling is an interesting tool for animal breeding where exact recursive peeling is generally unfeasible due to the abundant number of loops in animal pedigrees. In simulations hypothesis testing and parameter estimation were compared based on approximate likelihoods in looped pedigrees and exact likelihoods in nonlooped pedigrees showing no biases introduced by the approximation in looped pedigrees. likelihood pedigree peeling major gene I looped pedigree Resume Calcul approximatif de vraisemblance pour un modèle monogénique dans de grands pedigrees à boucles. Dans cette étude on introduit une procedure iterative de condensation de I information contenue dans un pedigree appelée épluchagev qui est équivalente à 1 épluchage recursif pour le calcul des vraisemblances exactes dans des pedigrees sans boucles mais qui est également utilisable pour le calcul de vraisemblances ap-proximatives dans les pedigrees à boucles. L épluchage iteratif est une méthode intéressante en génétique animate OÙ la methode recursive exacte est généralement inapplicable à cause du grand nombre de boucles dans les pedigrees animaux. A I aide de simulations on a compare des tests d hypothese et I estimation de paramètres bases sur des vraisemblances approximatives dans des pedigrees à boucles et des vraisemblances exactes dans des pedigrees sans boucles montrant qu il n y a pas de .

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