TAILIEUCHUNG - Báo cáo khoa hoc:"Analysis of response to 20 generations of selection for body composition in mice: fit to infinitesimal model assumptions"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Analysis of response to 20 generations of selection for body composition in mice: fit to infinitesimal model assumptions | Genet. Sel. Evol. 32 2000 3-21 INRA EDP Sciences 3 Original article Analysis of response to 20 generations of selection for body composition in mice fit to infinitesimal model assumptions Victor Martinez Lutz Bunger William G. Hill Institute of Cell Animal and Population Biology University of Edinburgh West Mains Road Edinburgh EH9 3JT UK Received 26 April 1999 accepted 2 December 1999 Abstract - Data were analysed from a divergent selection experiment for an indicator of body composition in the mouse the ratio of gonadal fat pad to body weight GFPR . Lines were selected for 20 generations for fat F lean L or were unselected C with three replicates of each. Selection was within full-sib families 16 families per replicate for the first seven generations eight subsequently. At generation 20 GFPR in the F lines was twice and in the L lines half that of C. A log transformation removed both asymmetry of response and heterogeneity of variance among lines and so was used throughout. Estimates of genetic variance and heritability approximately 50 obtained using REML with an animal model were very similar whether estimated from the first few generations of selection or from all 20 generations or from late generations having fitted pedigree. The estimates were also similar when estimated from selected or control lines. Estimates from REML also agreed with estimates of realised heritability. The results all accord with expectations under the infinitesimal model despite the four-fold changes in mean. Relaxed selection lines derived from generation 20 showed little regression in fatness after 40 generations without selection. selection infinitesimal model genetic variance body composition mouse Résumé Analyse de la reponse à la selection de 20 generations pour la composition corporelle des souris ajustee aux hypothàses du modàle infinitesimal. Les données provenant d un programme de selection divergente ont été analysées pour un indicateur de la composition corporelle des .

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