TAILIEUCHUNG - Báo cáo y học: " Protein structure protection commits gene expression patterns"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Protein structure protection commits gene expression patterns. | Open Access Research Protein structure protection commits gene expression patterns Jianping Chen Han Liang and Ariel Fernández Addresses Program in Applied Physics Rice Quantum Institute Rice University Houston TX 77005 USA. Department of Ecology and Evolution University of Chicago Chicago IL 60637 USA. Department of Bioengineering Rice University Houston TX 77005 USA. Department of Computer Science University of Chicago Chicago IL 60637 USA. Correspondence Ariel Fernández. Email arifer@ Published 7 July 2008 Genome Biology 2008 9 R107 doi gb-2008-9-7-r107 The electronic version of this article is the complete one and can be found online at http 2008 9 7 R107 Received 19 May 2008 Revised 6 July 2008 Accepted 7 July 2008 2008 Chen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gene co-expressions often determine module-defining spatial and temporal concurrences of proteins. Yet little effort has been devoted to tracing coordinating signals for expression correlations to the three-dimensional structures of gene products. Results We performed a global structure-based analysis of the yeast and human proteomes and contrasted this information against their respective transcriptome organizations obtained from comprehensive microarray data. We show that protein vulnerability quantifies dosage sensitivity for metabolic adaptation phases and tissue-specific patterns of mRNA expression determining the extent of co-expression similarity of binding partners. The role of protein intrinsic disorder in transcriptome organization is also delineated by interrelating vulnerability disorder propensity and co-expression patterns. Extremely vulnerable human proteins are shown to be .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.