TAILIEUCHUNG - Báo cáo sinh học: " Streamlined design of a self-inactivating feline immunodeficiency virus vector for transducing ex vivo dendritic cells and T lymphocytes"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Streamlined design of a self-inactivating feline immunodeficiency virus vector for transducing ex vivo dendritic cells and T lymphocytes | Genetic Vaccines and Therapy BioMed Central Research Open Access Streamlined design of a self-inactivating feline immunodeficiency virus vector for transducing ex vivo dendritic cells and T lymphocytes Mauro Pistello Laura Vannucci Alessia Ravani Francesca Bonci Flavia Chiuppesi Barbara Del Santo Giulia Freer and Mauro Bendinelli Address Retrovirus Center and Virology Section Department of Experimental Pathology University of Pisa Pisa Italy Email Mauro Pistello - pistello@ Laura Vannucci - lauravannucci@ Alessia Ravani - alessiaravani@ Francesca Bonci - Flavia Chiuppesi - flo83@ Barbara Del Santo - barbaradelsanto@ Giulia Freer - freer@ Mauro Bendinelli - bendinelli@ Corresponding author Published 19 September 2007 Received 13 June 2007 JTÌ . - -7 I Irtz I ZVI-I-Z I-rt Accepted 19 September 2007 Genetic Vaccines and Therapy 2007 5 8 doi l479-0556-5-8 This article is available from http content 5 1 8 2007 Pistello et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Safe and efficient vector systems for delivering antigens or immunomodulatory molecules to dendritic cells DCs T lymphocytes or both are considered effective means of eliciting adaptive immune responses and modulating their type extent and duration. As a possible tool toward this end we have developed a self-inactivating vector derived from feline immunodeficiency virus FIV showing performance characteristics similar to human immunodeficiency virus-derived vectors but devoid of the safety concerns these vectors have raised. Methods The pseudotyped FIV particles were generated with a .

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