TAILIEUCHUNG - Báo cáo sinh học: "Metabolic reconfiguration is a regulated response to oxidative stress"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Metabolic reconfiguration is a regulated response to oxidative stress. | Journal of Biology BioMed Central Minireview Metabolic reconfiguration is a regulated response to oxidative stress Chris M Grant Address Faculty of Life Sciences The University of Manchester Oxford Road Manchester M13 9PT UK. Email Published 25 January 2008 Journal of Biology 2008 7 1 doi jbiol63 The electronic version of this article is the complete one and can be found online at http content 7 1 1 2008 BioMed Central Ltd Abstract A new study reveals that in response to oxidative stress organisms can redirect their metabolic flux from glycolysis to the pentose phosphate pathway the pathway that provides the reducing power for the main cellular redox systems. This ability is conserved between yeast and animals showing its importance in the adaptation to oxidative stress. Organisms are exposed to reactive oxygen species ROS such as hydrogen peroxide and the superoxide anion during the course of normal aerobic metabolism or following exposure to radical-generating compounds. ROS cause wide-ranging damage to macromolecules which can eventually lead to cell death and thus to aging and a range of diseases 1 . To protect themselves against this damage cells have effective defense mechanisms including antioxidant enzymes and free radical scavengers 2 . It is now well established that most cells can adapt to oxidative stress by altering global gene-expression patterns including transcription and translation of genes encoding antioxidants and other metabolic enzymes. It is becoming increasingly recognized however that post-translational changes are key regulators of stress responses. A recent study in Journal of Biology 3 shows that dynamic rerouting of the metabolic flux to the pentose phosphate pathway with the concomitant generation of the reduced electron carrier nicotinamide adenine dinucleotide phosphate NADPH is a conserved post-translational response to oxidative stress. The pentose phosphate pathway is the source of .

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