TAILIEUCHUNG - Báo cáo sinh học: "Genome-wide mapping of Quantitative Trait Loci for fatness, fat cell characteristics and fat metabolism in three porcine F2 crosses"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Genome-wide mapping of Quantitative Trait Loci for fatness, fat cell characteristics and fat metabolism in three porcine F2 crosses | Geldermann et al. Genetics Selection Evolution 2010 42 31 http content 42 1 31 Ge n et i cs Selection Evolution RESEARCH Open Access Genome-wide mapping of Quantitative Trait Loci for fatness fat cell characteristics and fat metabolism in three porcine F2 crosses 1 I- I 2 2 3 3 Hermann Geldermann Stanislav Cepica Antonin Stratil Heinz Bartenschlager Siegfried Preuss Abstract Background QTL affecting fat deposition related performance traits have been considered in several studies and mapped on numerous porcine chromosomes. However activity of specific enzymes protein content and cell structure in fat tissue probably depend on a smaller number of genes than traits related to fat content in carcass. Thus in this work traits related to metabolic and cytological features of back fat tissue and fat related performance traits were investigated in a genome-wide QTL analysis. QTL similarities and differences were examined between three F2 crosses and between male and female animals. Methods A total of 966 F2 animals originating from crosses between Meishan M Pietrain P and European wild boar W were analysed for traits related to fat performance 11 enzymatic activity 9 and number and volume of fat cells 20 . Per cross 216 M X P 169 W X P and 195 W X M genome-wide distributed marker loci were genotyped. QTL mapping was performed separately for each cross in steps of 1 cM and steps were reduced when the distance between loci was shorter. The additive and dominant components of QTL positions were detected stepwise by using a multiple position model. Results A total of 147 genome-wide significant QTL 76 at P and 71 at P were detected for the three crosses. Most of the QTL were identified on SSC1 between 76-78 and 87-90 cM SSC7 predominantly in the MHC region and SSCX in the vicinity of the gene CAPN6 . Additional genome-wide significant QTL were found on SSC8 12 13 14 16 and 18. In many cases the QTL are mainly additive and differ between F2 .

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