TAILIEUCHUNG - Báo cáo khoa học: Malaria)the global disease

Malaria is a disease of global concern. Historically, malaria has killed more people than any other infec-tious disease and still accounts for massive levels of mortality and morbidity in over 100 countries of the world. In Africa and some other underdeveloped coun-tries mortality remains high because there is limited access to treatment in villages. | IFEBS Journal MINIREVIEW SERIES Malaria - the global disease Renu Tuteja Malaria Group InternationalCentre for Genetic Engineering and Biotechnology New Delhi India Malaria is a disease of global concern. Historically malaria has killed more people than any other infectious disease and still accounts for massive levels of mortality and morbidity in over 100 countries of the world. In Africa and some other underdeveloped countries mortality remains high because there is limited access to treatment in villages. Malaria parasites spread by successively infecting two types of hosts humans and female Anopheles mosquitoes. Four species of malaria parasite can infect humans under natural conditions Plasmodium falciparum Plasmodium vivax Plasmodium ovale and Plasmodium mala-riae. The first two cause the most infections worldwide. In humans the parasites grow and multiply first in the liver cells and then in the erythrocytes. Blood-stage parasites are responsible for causing the symptoms of malaria and the disease is diagnosed by its symptoms and the microscopic examination of blood. Malaria is completely curable but the emergence of drug-resistance in P. falciparum is a major obstacle to the control of the disease. Insecticide resistance in disease-transmitting mosquitoes makes it vital to understand the molecular background of the pathogenesis of malaria in order to facilitate the development of novel approaches to combat the disease. This minireview series provides an overview of the disease the progress towards vaccine development the problem of drug resistance and the development of one of the novel drug targets. The first minireview is an overview in which the author describes the various parasites and the life cycle and development of P. falciparum in red blood cells. Malaria symptoms the genome proteome and transcriptome information of P. falciparum are described in brief. The second minireview is an update on vaccine development against this devastating disease. .

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