TAILIEUCHUNG - Báo cáo y học: " Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs"

Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs | Xu et al. Virology Journal 2010 7 184 http content 7 1 184 VIROLOGY JOURNAL RESEARCH Open Access Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs 11 3 3t 1 1 31 Min Xu Shujie Wang Linxi Li Liancheng Lei Yonggang Liu Wenda Shi Jiabin Wu Liqin Li Fulong Rong4 Mingming Xu4 Guangli Sun4 Hua Xiang2 Xuehui Cai1 Abstract Background Porcine reproductive and respiratory syndrome virus PRRSV and Streptococcus suis are common pathogens in pigs. In samples collected during the porcine high fever syndrome PHFS outbreak in many parts of China PRRSV and S. suis serotype 7 SS7 have always been isolated together. To determine whether PRRSV-SS7 coinfection was the cause of the PHFS outbreak we evaluated the pathogenicity of PRRSV and or SS7 in a pig model of single and mixed infection. Results Respiratory disease diarrhea and anorexia were observed in all infected pigs. Signs of central nervous system CNS disease were observed in the highly pathogenic PRRSV HP-PRRSV -infected pigs 4 12 and the coinfected pigs 8 10 however the symptoms of the coinfected pigs were clearly more severe than those of the HP-PRRSV-infected pigs. The mortality rate was significantly higher in the coinfected pigs 8 10 than in the HP-PRRSV- 2 12 and SS7-infected pigs 0 10 . The deceased pigs of the coinfected group had symptoms typical of PHFS such as high fever anorexia and red coloration of the ears and the body. The isolation rates of HP-PRRSV and SS7 were higher and the lesion severity was greater in the coinfected pigs than in monoinfected pigs. Conclusion HP-PRRSV infection increased susceptibility to SS7 infection and coinfection of HP-PRRSV with SS7 significantly increased the pathogenicity of SS7 to pigs. Background Porcine reproductive and respiratory syndrome PRRS is a threat to the swine industry and has spread globally to almost every country involved in pig .

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