TAILIEUCHUNG - Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon

The type III secretion system (T3SS) is a complex macromolecular machin-ery employed by a number of Gram-negative species to initiate infection. Toxins secreted through the system are synthesized in the bacterial cyto-plasm and utilize the T3SS to pass through both bacterial membranes and the periplasm, thus being introduced directly into the eukaryotic cytoplasm. | ễFEBS Journal REVIEW ARTICLE Membrane targeting and pore formation by the type III secretion system translocon Pierre-Jean Mattei1 Eric Faudry2 Viviana Job1 Thierry Izore1 Ina Attree2 and Andrea Dessen1 1 BacterialPathogenesis Group Institut de Biologie Structurale UMR 5075 CNRS CEA UJF Grenoble France 2 BacterialPathogenesis and Cellular Responses Team Centre Nationalde la Recherche Scientifique CNRS Universite Joseph Fourier UJF LBBSI iRTSV CEA Grenoble France Keywords bacterial infection injection membrane pore formation secretion toxin Correspondence A. Dessen Bacterial Pathogenesis Group Institut de Biologie Structurale UMR 5075 CNRSCea UJF 41 rue Jules Horowitz 38027 Grenoble France Fax 33 4 38 78 54 94 Tel 33 4 38 78 95 90 E-mail Received 21 September 2010 revised 4 November 2010 accepted 26 November 2010 The type III secretion system T3SS is a complex macromolecular machinery employed by a number of Gram-negative species to initiate infection. Toxins secreted through the system are synthesized in the bacterial cytoplasm and utilize the T3SS to pass through both bacterial membranes and the periplasm thus being introduced directly into the eukaryotic cytoplasm. A key element of the T3SS of all bacterial pathogens is the translocon which comprises a pore that is inserted into the membrane of the target cell allowing toxin injection. Three macromolecular partners associate to form the translocon two are hydrophobic and one is hydrophilic and the latter also associates with the T3SS needle. In this review we discuss recent advances on the biochemical and structural characterization of the proteins involved in translocon formation as well as their participation in the modification of intracellular signalling pathways upon infection. Models of tran-slocon assembly and regulation are also discussed. doi Introduction Type III secretion systems T3SS are complex macromolecular machineries employed by a number of .

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