TAILIEUCHUNG - Báo cáo y học: "Can a simple blood test quantify brain injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Can a simple blood test quantify brain injury? | Available online http content 13 4 166 Commentary Can a simple blood test quantify brain injury Stephan A Mayer and Guillermo Linares Neurological Intensive Care Unit Milstein Hospital Building 177 Fort Washington Avenue Suite 8-300 Center New York NY 10032 USA Corresponding author Stephan A Mayer sam14@ Published 15 July 2009 Critical Care 2009 13 166 doi cc7929 This article is online at http content 13 4 166 2009 BioMed Central Ltd See related research by Derwall et al. http content 13 2 R58 Abstract Despite significant advances in neurocritical care it remains difficult to precisely measure the extent of neurological injury in patients affected by stroke trauma or cardiac arrest. In the intensive care unit the extent of primary and secondary injury often eludes clinicians making prognostication imprecise and difficult. Derwall and colleagues present their findings on the dynamics of serum S-100B protein levels in out-of-hospital cardiac arrest survivors. Their study suggests that elevation of S-100B reflects the severity of the primary hypoxic-ischemic insult. The first decade of the 21st century has witnessed explosive growth in therapies for the critically ill neurological patient. Some of these treatments such as the use of recombinant tissue plasminogen activator for the treatment of acute cerebral infarction target very specific pathogenic pathways. Others such as hypothermia for the treatment of brain injury after cardiac arrest have multiple additive and synergistic mechanisms of action that culminate in the protection of nervous tissue. To guide these treatments technological advances in imaging and neuromonitoring can now provide a window into the metabolic and physiologic status of the injured brain allowing us to evaluate the effect of our therapeutic interventions in real time. Despite these promising advances it remains difficult to precisely measure the extent of neurological injury in .

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