TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 82

Pharmaceutical Substances Syntheses, Patents, Applications - Part 82. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Etizolam E 811 Reference s DE 1 493 533 Chemie Grünenthal appl. . DAS 1 493 567 Chemie Grünenthal appl. . US3930017 ChemieGrünenthal D-prior. . US 4110 470 Chemie Grünenthal D-prior. . Formulation s cps. 20 mg Trade Name s D Skleronorm Grünenthal wfm Etizolam atc N05Bä19 noscd Use benzodiazepine tranquilizer anxiolytic sedative RN 40054-69-1 MF C17H15C1N4S MW LDso 4258-4358mg kg M . 5000 mg kg M . 3619-3509 mg kg R . 5000 mg kg R . CN 4- 2-chlorophenyl -2-ethyl-9-methyl-6H-thieno 3 2- l 2 4 triazolo 4 3-ia l 4 diazepine 2 -chloro-2-cyono- butyr- ocetophenone aldehyde 0 CH3COOH 1. N-benzyloxycarbonyl-qlycyl chloride CHjCOOH pyridine ------------------ 2-amino-3- 2-chlarobenzayl -5-ethylthiophene p2s5 phosphorus pentasulfide nh2 I 5- 2-chlorophenyQ- 1 3-dihydro-7-ethyl-2H-thieno- 2 3-e -1 4-diazepin-2-one 812 E Etodolac Reference s Nakanishi M. et al. J. Med. Chem. JMCMAR 16 214 1973 . Nakanishi M. et al. . ARZNAD 22 1905 1972 . Tañara T. et al. . ARZNAD 28 1153 1978 . DOS 2 229 845 Yoshitomi appl. J-prior. . US 3 904 641 Yoshitomi J-prior. . Formulation s drops mg 1 mg Trade Name s I Depas Pierrel Pasaden Farmades J Depas Yoshitomi Etodolac ATC M01AB08 Etodolic acid Etodolsaure Use anti-inflammatory analgesic RN 41340-25-4 MF C17H21NO3 MW LD50 593 mg kg M . 94 mg kg R . CN 1 8-diethyl-1 3 4 9-tetrahydropyrano 3 4- indole-l -acetic acid 2-ethyl-aniline NaNO2 HCI ------------ 2-ethyl benzenediazonium chloride 2-ethylphenyl-hydrazine I Etodolac Etodroxizine E 813 Reference s US 3 939 178 American Home Products appl. . US 3 843 681 American Home Products appl. . GB 1 391 005 American Home Products appl. USA-prior. . DOS 2 226 340 American

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