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Pharmaceutical Substances Syntheses, Patents, Applications - Part 82. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Etizolam E 811 Reference s DE 1 493 533 Chemie Grünenthal appl. 10.4.1964 . DAS 1 493 567 Chemie Grünenthal appl. 7.10.1965 . US3930017 ChemieGrünenthal 30.12.1975 D-prior. 7.10.1965 . US 4110 470 Chemie Grünenthal 29.8.1978 D-prior. 7.10.1965 . Formulation s cps. 20 mg Trade Name s D Skleronorm Grünenthal wfm Etizolam atc N05Bä19 noscd Use benzodiazepine tranquilizer anxiolytic sedative RN 40054-69-1 MF C17H15C1N4S MW 342.85 LDso 4258-4358mg kg M p.o. 5000 mg kg M s.c. 3619-3509 mg kg R p.o. 5000 mg kg R s.c. CN 4- 2-chlorophenyl -2-ethyl-9-methyl-6H-thieno 3 2- l 2 4 triazolo 4 3-ia l 4 diazepine 2 -chloro-2-cyono- butyr- ocetophenone aldehyde 0 2.HBr CH3COOH 1. N-benzyloxycarbonyl-qlycyl chloride CHjCOOH pyridine ------------------ 2-amino-3- 2-chlarobenzayl -5-ethylthiophene p2s5 phosphorus pentasulfide nh2 I 5- 2-chlorophenyQ- 1 3-dihydro-7-ethyl-2H-thieno- 2 3-e -1 4-diazepin-2-one 812 E Etodolac Reference s Nakanishi M. et al. J. Med. Chem. JMCMAR 16 214 1973 . Nakanishi M. et al. Arzneim.-Forsch. ARZNAD 22 1905 1972 . Tañara T. et al. Arzneim.-Forsch. ARZNAD 28 1153 1978 . DOS 2 229 845 Yoshitomi appl. 19.6.1972 J-prior. 18.6.1971 21.6.1971 30.6.1971 8.7.1971 10.7.1971 13.7.1971 . US 3 904 641 Yoshitomi 9.9.1975 J-prior. 18.6.1971 21.6.1971 30.6.1971 8.7.1971 10.7.1971 13.7.1971 . Formulation s drops 0.05 tabl.0.5 mg 1 mg Trade Name s I Depas Pierrel Pasaden Farmades J Depas Yoshitomi Etodolac ATC M01AB08 Etodolic acid Etodolsaure Use anti-inflammatory analgesic RN 41340-25-4 MF C17H21NO3 MW 287.36 LD50 593 mg kg M p.o. 94 mg kg R p.o. CN 1 8-diethyl-1 3 4 9-tetrahydropyrano 3 4- indole-l -acetic acid 2-ethyl-aniline NaNO2 HCI ------------ 2-ethyl benzenediazonium chloride 2-ethylphenyl-hydrazine I Etodolac Etodroxizine E 813 Reference s US 3 939 178 American Home Products 17.2.1976 appl. 15.9.1972 . US 3 843 681 American Home Products 22.10.1974 appl. 1.6.1971 . GB 1 391 005 American Home Products appl. 1.6.1972 USA-prior. 1.6.1971 . DOS 2 226 340 American
