TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 48

Pharmaceutical Substances Syntheses, Patents, Applications - Part 48. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Cimetidine C 471 Reference s DOS 2 934 747 Otsuka appl. J-prior. . US 4 277 479 Otsuka J-prior. . . Chem. Pharm. Bull. CPBTAL 31 1151 1983 . medical use for treatment of nephritis JP2 178 227 Otsuka appl. . medical use for treatment of Raynaud s syndrome JP 2 178 226 Otsuka appl. . Formulation s tabl. 50 mg 100 mg Trade Namets J Pletaal Otsuka Retal Otsuka 1988 Cimetidine ATC A02BA01 Use peptic ulcer therapeutic H2-receptor antagonist RN 51481-61-9 MF C10H16N6S MW EINECS 257-232-2 LD50 150 mg kg M . 2550 mg kg M . 106 mg kg R . 5 g kg R . 206 mg kg dog . 2600 mg kg dog . CN lV-cyano-W-methyl-7V - 2- 5-methyl-l 77-imidazol-4-yl methyl thio ethyl guanidine ethyl 2-chloro-ocetoocetate H N CHO Cl 2 0 Na liq. NH- ethyl 5-methyl-imidazole-4- o IjC-2 o HCI formamide carboxylate HO- 4- hydroxymethyl- 5- methylimidazole hydrochloride I H H C XN. 2HCI cysteamine hydrochloride 4- 2-aminoethylthio - methyl -5-methyl- imidozole dihydrochlaride CN H3C A xCH3 --------- ------------ II dimethyl cyano-carboimidodithioate from cyanamide KOH carbon disulfide and dimethyl sulfate Reference s US 3 894 151 Smith Kline French GB-prior. . US4000 302 Smith Kline French GB-prior. . DOS 2 320 131 Smith Kline French appl. GB-prior. - medical use. DOS 2344 779 Smith Kline French appl. GB-prior. and . US 3 950 333 Smith Kline French appl. prior. and . 472 C Cimetropium bromide cimetidine A DOS 2 742 531 Smith Kline French appl. GB-prior. . GB 1 543 238 Smith Kline French appl. valid from . precursors and alternative methods DOS 2 637 670 Smith Kline French appl. USA-prior. and . FR 2 321 490 Smith Kline French appl. USA-prior. and . GB 1 338 169 .

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