TAILIEUCHUNG - CLINICAL PHARMACOLOGY 2003 (PART 9A)

How drugs act and interact, how they enter the body, what happens to them inside the body, how they are eliminated from it; the effects of genetics, age, and disease on drug action — these topics are important for, although they will generally not be in the front of the conscious mind of the prescriber, an understanding of them will enhance rational decision taking. Knowledge of the requirements for success and the explanations for failure and for adverse events will enable the doctor to maximise the benefits and minimise the risks of drug therapy. Pharmacodynamics. Qualitative aspects: Receptors, Enzymes,. | SECTION 2 FROM PHARMACOLOGY TO TOXICOLOGY This page intentionally left blank General pharmacology SYNOPSIS How drugs act and interact how they enter the body what happens to them inside the body how they are eliminated from it the effects of genetics age and disease on drug action these topics are important for although they will generally not be in the front of the conscious mind of the understanding of them will enhance rational decision taking. Knowledge of the requirements for success and the explanations for failure and for adverse events will enable the doctor to maximise the benefits and minimise the risks of drug therapy. Pharmacodynamics Qualitative aspects Receptors Enzymes Selectivity Quantitative aspects Dose response Potency Therapeutic efficacy Tolerance Pharmacokinetics Time course of drug concentration Drug passage across cell membranes Order of reaction Plasma half-life and steady-state concentration Therapeutic drug monitoring Individual processes Absorption Distribution Metabolism Elimination SYNOPSIS CONTINUED Drug dosage Dosing schedules Chronic pharmacology the consequences of prolonged drug administration and drug discontinuation syndromes Individual or biological variation Variability due to inherited influences environmental and host influences Drug interactions outside the body at site of absorption during distribution directly on receptors during metabolism during excretion Pharmacodynamics is what drugs do to the body pharmacokinetics is what the body does to drugs It is self-evident that knowledge of pharmacodynamics is essential to the choice of drug therapy. But the well-chosen drug may fail to produce benefit or may be poisonous because too little or too much is present at the site of action for too short or too long a time. Drug therapy can fail for pharmacokinetic as well as for pharmacodynamic reasons. The practice of drug therapy entails more than remembering an apparently arbitrary list of actions or indications. .

• Y học thường thức
• General pharmacology
• from pharmacology to toxicology
• clinical pharmacology
• sách học ngành dược
• dược lý lâm sàng
• tài liệu học dược sĩ
• độc dược
• General and molecular pharmacology
• Molecular pharmacology
• Essential lexicon
• A short history of pharmacology
• Drug absorption
• Drug metabolism
• Colour atlas of pharmacology
• Systems pharmacology
• cellular sites of action
• Distribution in the body
• Drug plasma concentration
• Qualitative aspects
• Drug dependence
• Calcium homeostasis within the cells
• Viva voce in medical pharmacology
• Medical pharmacology
• Autonomic nervous system
• Central nervous system
• Cadiovascular system
• General Anesthetic Drugs
• Color Atlas of Pharmacology
• bản đồ màu của dược
• giáo trình dược sĩ
• tài liệu học ngành dược
• bảo quản thuốc
• thuốc trị bệnh
• bào chế thuốc
• drug therapy
• Antibacterial drugs
• bacterial infections
• antiinflammatory drugs
• Adrenal corticosteroids
• Medical pharmacology at a glance
• Lipid lowering drugs
• General anaesthetics
• Agents used in anaemias
• Anxiolytics and hypnotics
• Antiepileptic drugs
• Antipsychotic drugs
• BMC Pharmacology and Toxicology
• Drug prescriptions
• General practice
• Practice guidelines as topic
• Antiviral drugs during
• Related Analgesics
• Morphine Derivatives
• Cinchona Alkaloids
• RauwolJia Alkaloids
• Erythrophleum
• Drug action
• Drug interaction
• Pharmacokinetic modelling
• Applied pharmacokinetic models
• Medicinal chemistry
• General anaesthetic agents
• Adverse drug reactions
• Spontaneous reporting
• Modified drug administration guidelines
• Clinical manifestations
• Drug use
• Psychotropic drugs
• Retrospective study
• Z drugs
• Antibiotic use
• Continuity of care
• Primary care physician
• Antihypertensive drug therapy
• Prospective study
• Blood pressure
• Calcium channel blockers
• Local Anaesthesia
• Local Anaesthesia in Dentistry
• Impulse conduction
• Anatomy of the trigeminal nerve
• Pharmacology of local anaesthetics
• General practical aspects
• medical books
• pharmacology
• epidemiologic
• Obstetrics
• anatomy
• Preventing Morbidity
• Multidisciplinary Care