TAILIEUCHUNG - Structure and cytotoxic activity of a sulfated polysaccharide from green seaweed Caulerpa racemose collected on Nha Trang bay, Viet Nam

In this work, a new sulfated polysaccharide was isolated from green seaweed Caulerpa racemosa harvested at Nha Trang sea. The structure of obtained polysaccharide was determined and its cytotoxic activity was evaluated. The results showed that structure of the polysaccharide has a main chain of (1→4)-β-D-galactopyranose residues and branches are (1→3)-α-L-glucopyranose-2,4-disulfate residues linked to the main chain at C-6 position. | Cite this paper Vietnam J. Chem. 2023 61 S3 59-64 Research Article DOI Structure and cytotoxic activity of a sulfated polysaccharide from green seaweed Caulerpa racemose collected on Nha Trang bay Viet Nam Quach Thi Minh Thu1 Dang Vu Luong1 Nguyen Quang Tam1 Nguyen Thi Nu2 Le Thi Hong Nhung3 Thanh Thi Thu Thuy1 1 Institute of Chemistry Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Cau Giay Hanoi 10000 Viet Nam 2 Hanoi Metropolitan University 98 Duong Quang Ham Cau Giay Hanoi 10000 Viet Nam 3 Hanoi University of Industry 298D Cau Dien Nam Tu Liem Hanoi 10000 Viet Nam Submitted February 18 2023 Revised April 24 2023 Accepted May 19 2023 Abstract In this work a new sulfated polysaccharide was isolated from green seaweed Caulerpa racemosa harvested at Nha Trang sea. The structure of obtained polysaccharide was determined and its cytotoxic activity was evaluated. The results showed that structure of the polysaccharide has a main chain of 1 4 -β-D-galactopyranose residues and branches are 1 3 -α-L-glucopyranose-2 4-disulfate residues linked to the main chain at C-6 position. The sulfated polysaccharide showed cytotoxic activity against three cancer cell lines Hela cervical cancer HT29 human colorectal adenocarcinoma and 8505c human undifferentiated thyroid carcinomas with IC50 values of and µg mL respectively Keywords. Sulfated polysaccharide green seaweed Caulerpa racemosa structure cytotoxic activity. 1. INTRODUCTION exhibited inhibition effect on K562 cells in both in vitro and in vivo Cavas et al. 8 investigated the Green seaweeds belonging to the Chlorophyta antiproliferative and apoptotic effects of sulfated division are found in both marine and freshwater. polysaccharide from C. racemosa collected at They are rich sources of sulfated polysaccharides Mediterranean Sea. A sulfated polysaccharide with anticoagulant activity 1 cytotoxic activity 2 contained galactose glucose arabinose and xylose .

• Địa Lý
• Sulfated polysaccharide
• Green seaweed
• Caulerpa racemosa
• Cytotoxic activity
• Anticoagulant activity
• Caulerpa taxifolia
• Vietnam Journal of Chemistry
• Conformational structure of tamarind seed polysaccharide
• Sulfated derivative by light scattering method
• Native tamarind seed polysaccharide
• Sphere like molecule
• Rong nâu Hormophysa articulata
• Cột sắc ký DEAE cellulose
• Chất chống đông cục máu
• Cấu trúc dạng galactofucan sulfate
• Antioxidant activity
• Betaphycus gelatinus
• Red algae
• Red algae Betaphycus gelatinus
• Red seaweed
• Acanthophora spicifera
• Determination of sulfated polysaccharide
• Red seaweed Acanthophora spicifera
• NMR methods
• scientific reports
• Report medicine
• traditional medicine
• oxidation
• chemical reaction
• tumor cells