TAILIEUCHUNG - HO - initiated oxidation of isoleucine amino acid in the aqueous phase

The results showed that the overall diffusioncontrolled rate constant is equal to ×109 M-1 s -1 at . The zwitterionic form is the main existing form that plays an essential role in the HO - initiated oxidation of Ile (). The most preponderant reactions are found at C6-H () and C8-H () positions. Finally, the influence of temperature on the overall rate is also evaluated. | Cite this paper Vietnam J. Chem. 2023 61 S1 37-44 Research article DOI HO - initiated oxidation of isoleucine amino acid in the aqueous phase Nguyen Thi Huong Lan1 Truong Dinh Hieu1 2 Ngo Thi Chinh1 2 Nguyen Thi Le Anh1 2 Pham Thi Yen Nhi2 Dao Duy Quang1 2 1 Faculty of Pharmacy Duy Tan University Da Nang 55000 Viet Nam 2 Institute of Research and Development Duy Tan University Da Nang 55000 Viet Nam Submitted Revised Accepted Abstract Protein damage by the direct oxidative attack on amino acid side chains is considered the main cause of human aging and diseases. Therefore a better understanding of the oxidation process is necessary for screening and designing new drugs. In this work the oxidation of L-isoleucine Ile by HO radical was mechanistically and kinetically studied using M05-2X 6-311 G 3df 3pd M05-2X 6-311 G d p level of theory. All possible hydrogen transfer HT and single electron transfer SET reactions are considered in the aqueous phase. The results showed that the overall diffusion- controlled rate constant is equal to 109 M-1s-1 at . The zwitterionic form is the main existing form that plays an essential role in the HO - initiated oxidation of Ile . The most preponderant reactions are found at C6-H and C8-H positions. Finally the influence of temperature on the overall rate is also evaluated. Keywords. Amino acid oxidation free radical kinetics DFT hydrogen transfer SET. 1. INTRODUCTION or a carboxylic acid whereas the latter leads to the Fenton reaction-based production of hydroxyl radical Amino acids contain the amino -NH2 NH3 and or anion HO or HO that damages biomolecules. For carboxylic -COOH COO groups. 1 They are example Schöneich 14 studied the reaction mechanism naturally abundant in humans animals plants and of methionine Met oxidation by ROS. The results microorganisms. Currently approximately 500 illustrated that Met donates one or two electrons natural amino acids have been identified.

• Sinh học
• Amino acid
• Free radical
• Hydrogen transfer
• Reactive oxygen specie
• Certain physiological processes
• tính chất hóa học
• nhận biết hóa học
• chuỗi phản ứng hóa học
• tính chất lý hóa amino acid
• phân loại amino acid
• amino acid thường gặp
• amino acid ít gặp
• tính tan amino acid
• Fish amino acid
• Egg amino acid
• Recommended dose of fertilizers
• Total chlorophyll
• Soluble protein
• CGR and yield
• Modeling amino acid substitutions for whole genomes
• Modeling amino acid substitutions
• Amino acid substitution models
• Maximum likelihood estimation
• Plant genome datasets
• Bài giảng Hóa sinh đại cương
• Hóa sinh đại cương
• Chuyển hóa protein
• Chuyển hóa amino acid
• Sinh tổng hợp amino acid
• BMC Plant Biology
• Fatty acid amino acid conjugates
• Jasmonic acid
• Mitogen activated protein kinase
• Nicotiana attenuata
• Systemic response
• Amino acid profile
• Essential amino acid
• Anti nutritional content
• Traditionally consumed six wild vegetables
• Nonessential amino acids
• Sinh hóa động
• sự biến dưỡng protein
• sự biến dưỡng amino acid
• Sự khử carboxyl của amino acid
• Tiến trình tổng hợp protein
• Principles of biochemistry
• Lecture Principles of biochemistry
• Nguyên lý hóa sinh
• Biochemical compounds
• Amino acid metabolism
• Nitrogen assimilation
• Hóa sinh động vật
• Trao đổi amino acid và protein
• Đặc điểm trao đổi protein ở động vật
• Chuyển hoá amino acid
• Sinh tổng hợp protein
• Tạo dòng 30 amino acid
• Vùng đầu C biểu hiện
• 30 amino acid vùng đầu C
• Độc tố vi khuẩn Clostridium perfringens
• Thụ thể Claudin 4
• Tế bào M in vivo
• BMC Cancer
• Branched chain amino acid transaminase 1
• DNA damaging
• 4 aminobutyrate aminotransferase
• Glutamate decarboxylase 1
• Biliary tract cancer
• Amino acid transporter
• Prognostic factor
• L type amino acid transporter 1
• Fructosyl amino acid oxidase
• FAOX TE
• Expression and purification
• Escherichia Coli
• Cloning of fructosyl amino acid oxidase
• Amino ketone
• Organic acid
• Mannich reaction
• Synthesis of β amino ketones
• Component Mannich reaction
• Sulfanilic acid catalysed one pot
• Journal of Chemistry
• Dextran amino acid esters
• Potentiometric titration
• Polyelectrolyte titration
• Charging behavior
• Pharmaceutical crystallization in CouetteTaylor crystallizer
• Polymorphism of amino acid L glutamic acid
• The model crystal product
• Stable phase β form crystal
• Plant Biology
• Gamma aminobutyric acid
• NaCl stress
• SlGAD transcriptional expression
• Amino acid accumulation
• Reactive oxygen species metabolism
• Giáo khoa hóa hữu cơ
• amino axit
• axit amin
• hợp chất hữu cơ
• hóa hữ cơ
• Seasonal change
• Free amino acids
• Liquid chromatography
• Cultivation practices
• BMC Chemistry
• L α Amino acid
• Oxygen free ternary complexes
• Starting materia
• Semi conductive Co(II) complex
• Amino acids
• Triple negative
• Stress response
• Cancer cells
• Renal cell carcinoma
• L amino acid transporter
• Human renal cancer
• Lung cancer
• Early detection
• Multivariate discrimination index
• scientific reports
• Report medicine
• traditional medicine
• Structural biochemistry
• oxidation
• bacteria