TAILIEUCHUNG - Alpha‑1 antitrypsin deficiency and risk of lung cancer in never‑smokers: A multicentre case–control study

Lung cancer (LC) is the most commonly diagnosed cancer and the leading cause of cancer-related death in both sexes worldwide. Although the principal risk factor in the western world is tobacco smoking, genetic factors, including alpha-1 antitrypsin deficiency (AATD), have been associated with increased risk. | Tubío Pérez et al. BMC Cancer 2022 22 81 https s12885-022-09190-3 RESEARCH Open Access Alpha 1 antitrypsin deficiency and risk of lung cancer in never smokers a multicentre case control study Ramón Antonio Tubío Pérez1 María Torres Durán1 María Esmeralda García Rodríguez1 Cristina Candal Pedreira2 Julia Rey Brandariz2 Mónica Pérez Ríos3 Juan Barros Dios3 Alberto Fernández Villar1 and Alberto Ruano Raviña3 Abstract Background Lung cancer LC is the most commonly diagnosed cancer and the leading cause of cancer-related death in both sexes worldwide. Although the principal risk factor in the western world is tobacco smoking genetic factors including alpha-1 antitrypsin deficiency AATD have been associated with increased risk. This study is the continuation of an earlier one published by the same group in 2015 aimed at analysing risk of LC in never-smokers associated with carriers of the AATD genotype. Methods A multicentre case control study was conducted in Spain across the period January 2011 to August 2019. Cases were non-smokers diagnosed with LC and controls were composed of never-smoking individuals undergoing major non-cancer-related surgery. Data were collected on epidemiological characteristics exposure to environmental tobacco smoke ETS residential radon levels and alpha-1 antitrypsin AAT genotype. Results The study included 457 cases 42 and 631 controls 58 with a predominance of women 72 8 . The most frequent histological type was adenocarcinoma followed by squamous cell carcinoma . No asso ciation of risk of LC was found with the status of AATD genotype carrier both overall and broken down by age sex or exposure to ETS. Conclusions No risk association was found between being a carrier of an AAT deficiency genotype and LC among never-smokers. In order to establish the existence of an association we consider it important to expand the studies in never smokers in different geographical areas as well as to include patients with .

• Y khoa - Dược
• BMC Cancer
• Alpha 1 antitrypsin
• Lung cancer
• Never smokers
• Cancer related death
• Including alpha 1 antitrypsin deficiency
• Cancer patient pathways
• Colorectal cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
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• Total number of lymph nodes
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• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study