TAILIEUCHUNG - Synthesis, characterization and cytotoxic activity of PT(II)complex of camphor 4-methyl thiosemicarbazone
The development of drug delivery systems in the last several decades has provided a variety of methods including the synthesis new Pt(II), Pt(IV) complexes, the incorporation of drugs into liposome’s, lipid emulsions, and polymeric micelles to reduce side effects, to increase their solubility, and to prolong circulation time as well. Camphor has bioactivity, it has been used in traditional medicine from time immemorial. | Synthesis, characterization and cytotoxic activity of PT(II)complex of camphor 4-methyl thiosemicarbazone Vietnam Journal of Science and Technology 56 (2A) (2018) 75-80 SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY OF Pt(II)COMPLEX OF CAMPHOR 4-METHYL THIOSEMICARBAZONE Phan Thi Hong Tuyet1, *, Nguyen Hoa Du1, Le The Tam1, Nguyen Linh Toan2, Ha Thi Nhat Tan1 1 Vinh University, 182 Le Duan Street, Vinh City, Viet Nam 2 Vietnam Military Medical University 103, 160 Phung Hung, Ha Dong, Ha Noi, Viet Nam * Email: hongtuyetdhv@, tuyetph@ Received: 12 March 2018; Accepted for publication: 14 May 2018 ABSTRACT The new complex of Pt(II) with camphor 4-methyl thiosemicarbazone was synthesized and characterized by means of MS, 1H-NMR and IR spectroscopes. Results show that, the molecular formula of new Pt(II) complex is [Pt(C12H20N3S))2]. The Pt(II) complex is of four coordinate. The result of in vitro anti-cancer activity of the complex has shown that the complex of Pt(II) with camphor 4-methyl thiosemicarbazone exhibit inhibitor on Hep-G2 and RD cancer cells with IC50 values of and . These results indicated a potential of new Pt(II)complex in biomedical application. Keywords: camphor 4-methyl thiosemicarbazone, complex of Pt(II). 1. INTRODUCTION The anticancer drugs base on Platinum complexes are the mainstay of chemotherapy regimens in clinic. However, the efficacy of platinum drugs is badly affected by systemic toxicities and drug resistance, and the pharmacokinetics of most platinum drugs is largely unknown [1, 2, 3]. In recent years, platinum complexes with bioactive molecules, natural compounds, targeting groups or nonmaterial’s has been interested by chemical and biomedical researchers [4, 5, 6]. The motivation comes from some of the following demands: improve the selectivity or minimize the systemic toxicity of the drugs, enhance the cellular accumulation .
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