TAILIEUCHUNG - Acute inflammation induces immunomodulatory effects on myeloid cells associated with anti-tumor responses in a tumor mouse model

Given the self nature of cancer, anti-tumor immune response is weak. As such, acute inflammation induced by microbial products can induce signals that result in initiation of an inflammatory cascade that helps activation of immune cells. We aimed to compare the nature and magnitude of acute inflammation induced by toll-like receptor ligands (TLRLs) on the tumor growth and the associated inflammatory immune responses. To induce acute inflammation in tumor-bearing host, CD1 mice were inoculated with intraperitoneal (.) injection of Ehrlich ascites carcinoma (EAC) (5 • 105 cells/mouse), and then treated with . injection on day 1, day 7 or days 1 + 7 with: (1) polyinosinic:polycytidylic (poly(I:C)) (TLR3L); (2) Poly-ICLC (clinical grade of TLR3L); (3) Bacillus Calmette Guerin (BCG) (coding for TLR9L); (4) Complete Freund’s adjuvant (CFA) (coding for TLR9L); and (5) Incomplete Freund’s Adjuvant (IFA). Treatment with poly(I:C), Poly-ICLC, BCG, CFA, or IFA induced anti-tumor activities as measured by , , , and decreases, respectively in the total number of tumor cells collected 7 days after tumor challenge. | Acute inflammation induces immunomodulatory effects on myeloid cells associated with anti-tumor responses in a tumor mouse model

• Y khoa - Dược
• Ehrlich ascite carcinoma
• Acute inflammation induces immunomodulatory
• Myeloid cells associated
• Anti tumor responses
• Tumor mouse model
• BMC Cancer
• Protocadherin 10 isoforms
• Tumor suppression
• Conditional gene knockout
• Mouse medulloblastoma model
• Mouse auricular tumors
• Turkish Journal of Biology
• Tạp chí Sinh học
• RGS1 serves
• NICN87 DR cells
• Gastric cancer mouse model
• Epithelial mesenchymal transition
• Phage display
• Ovarian cancer
• Tumor cell viability
• Nude mouse tumor model
• BMC Pharmacology and Toxicology
• Anti tumor activity
• Cancer cell lines
• Cellular disassembly
• 2 pyridinethiol 1 oxide
• Hepatocellular carcinoma
• Hepatitis B
• Mouse model
• Gene expression
• Regulatory network
• Metronomic cyclophosphamide
• Immune responsiveness
• NK cells
• RNA seq
• Upstream regulator
• Drug schedule
• Lung cancer
• Kinase and phosphatase inhibitors
• Tumor angiogenesis
• Lung tumors
• Semliki Forest virus
• Cytotoxic effect
• 5 fluorouracil
• Combined cancer treatment
• 4 T1 tumor
• Immune checkpoint blockade
• Syngeneic model
• Cancer patients
• BMC Biotechnology
• Neural cell adhesion molecule
• ER intrabodies
• Polysialic acid cell surface expression
• Xenograft tumor mouse model
• báo cáo khoa học
• báo cáo sinh học
• công trình nghiên cứu về sinh học
• tài liệu về sinh học
• cách trình bày báo cáo
• trình bày báo cáo
• tài liệu báo cáo khoa học
• báo cáo y học
• kiến thức y học
• nghiên cứu y học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• Orthotopic xenograft models
• Small animal multimodal imaging
• Magnetic resonance imaging
• Optical imaging
• Transurethral instillation
• Fascin 1
• Xenograft mouse model
• Actin bundling protein
• Human carcinomas
• Synchrotron radiation
• In line phase contrast imaging
• Computed tomography
• Tumor neovascularization
• Hypoxia inducible factor 2 alpha
• Placental growth factor
• Extramedullary erythropoiesis
• VHL mutations
• Perfluorooctane sulfonate
• Colorectal cancer
• Dose–response
• Current chemotherapeutic
• Drug resistance underscore
• Gastric cancer
• Mouse models
• Human gastric cancer
• Tumor formation
• Res increased miR 34c
• Chemotherapeutic drugs
• Tumor bearing mouse model
• PI3K/Akt pathway
• Reactive gliosis
• Primary brain tumor
• Highly heterogene
• Human GBM cells
• Small sized polymeric micelles
• 4T1 Mammary carcinoma
• Malignant breast cancer
• Primary tumor resected
• Pancreatic cancer
• Tumor necrosis factor alpha
• Deadliest cancers
• Monocyte chemotactic protein 1
• Glucose 6 phosphate dehydrogenase
• Nude mice
• Signal transduction
• Transcription activator