TAILIEUCHUNG - Diagnostic value of ultrasound elastography in thyroid cancer

jectives: To describe some clinical features of thyroid nodules, B-mode ultrasound, Doppler and strain elastography in order to differentiate benign from malignant tumors. Subjects and methods: 72 patients with thyroid nodules were performed clinical examination, 2D ultrasound, Doppler and strain elastography for qualitative assessment of the stiffness of thyroid tumors according to Asteria scores (2008) from ES1 - ES4, semi-quantitative calculating elasticity of the tumors (E2) and normal parenchyma (E1), strain ratio: SR = E2/E1, comparing with fine needle aspiration results. | Journal of military pharmaco-medicine no1-2019 DIAGNOSTIC VALUE OF ULTRASOUND ELASTOGRAPHY IN THYROID CANCER Hoang Dinh Anh1; Pham Thi Dieu Huong1; Nguyen Thi Hoang Oanh1 Nguyen Minh Hai1; Nguyen Thi Ha1; Nguyen Thi Ly1; Nguyen Vu Thang1 SUMMARY Objectives: To describe some clinical features of thyroid nodules, B-mode ultrasound, Doppler and strain elastography in order to differentiate benign from malignant tumors. Subjects and methods: 72 patients with thyroid nodules were performed clinical examination, 2D ultrasound, Doppler and strain elastography for qualitative assessment of the stiffness of thyroid tumors according to Asteria scores (2008) from ES1 - ES4, semi-quantitative calculating elasticity of the tumors (E2) and normal parenchyma (E1), strain ratio: SR = E2/E1, comparing with fine needle aspiration results. Results: The study group had mean age of ± , most of them were female. B-mode ultrasound: suspicious features of malignance: ill-defined margin (50%); tallerthan-wide (); micro-calcification (). Ultrasound elastography: of patients were classified as ES3 (hard) and ES4 (very hard); strain ratio SR: ± . A comparison of these results with post-operative biopsy showed that the highest sensitivity and specificity were obtained with SR ≥ . Conclusion: Qualitative assessment of the elasticity of lesions using color map in combination with calculating mean strain ratio of the whole lesion (SR ≥ ) would help to evaluate more exactly the stiffness of lesions on elastography to assess thyroid cancer. * Keywords: Thyroid tumor; Ultrasound elastography; Diagnosis. INTRODUCTION Thyroid nodule is the second most common endocrine disease, after diabetes. The prevalence of the disease diagnosed by physical examination only accounts for 4 - 7%. However, with ultrasound technology, the rate of thyroid nodule detection may reach to 19 - 67%. More than 90% of thyroid tumors are benign adenomas and cysts, only 5 - 10% are .

• Y khoa - Dược
• Thyroid tumor
• Ultrasound elastography
• Thyroid cancer
• Semi quantitative
• Normal parenchyma
• Anaplastic thyroid carcinoma
• Rare tumor of thyroid gland
• Sarcoma of thyroid gland
• Differentiate thyroid carcinomas
• Fine needle aspiration cytology
• BMC Cancer
• Thyroid nodules
• Growth kinetics
• Growth rates
• Tumor growth
• Thyroid carcinomas
• Thyroid adenomas
• Differentiated thyroid carcinomas
• Papillary thyroid cancer
• Tumor associated calcium signal transducer 2
• Anaplastic thyroid cancer
• Differentiated thyroid cancer
• Tumor burden
• Risk stratification
• American Thyroid Association
• Follicular thyroid carcinoma
• Follicular adenoma
• Tumor associated macrophages
• Cross calibration
• Differentiated thyroid carcinoma
• Negative neck ultrasonography
• Tumor suppressor
• Thyroid lesions
• Thyroid papillary carcinoma
• Fine needle aspiration
• BMC Veterinary Research
• Congenital goiter
• Signet ring cell
• Thyroid metabolic disorder
• Thyroid stimulating hormone
• BRAF mutation
• mRNA mutation assay
• Triggers downstream oncogenic signaling
• Tumor DNA
• Papillary thyroid carcinoma
• Age at diagnosis
• Tumor size
• Lymph node metastasis
• SEER database
• Gene expression
• Thyroid tumour
• Ubiquitous multifunctional factor
• Neoplastic transformation
• Extrathyroidal extension
• Central lymph node metastasis
• Confidence interval
• DNA methylation
• Metallothionein 1G
• PI3K/Akt pathway
• Rb/E2F pathway
• Papillary thyroid microcarcinoma
• Tumor invasion and metastasis
• Distant metastasis
• Severely threatening
• Human mesenchymal stem cells
• Breast cancer
• CAL62 cells
• Bioluminescent imaging
• Cell migration
• Tumor invasiveness
• Invade surrounding
• Regulatory mechanisms
• Cancer cells
• Oncocytic carcinoma
• Nuclear mitochondrial complex I subunits
• Oncogene mutation analysis
• Mitochondrial abundance
• Ectopic TSH secreting pituitary adenoma
• Resistance to thyroid hormone
• TRH stimulating test
• Octreotide inhibition test