TAILIEUCHUNG - Potential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: Biochemical and histopathological evaluation

Silymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. | Turkish Journal of Biology Turk J Biol (2016) 40: 807-814 © TÜBİTAK doi: Research Article Potential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation 1 2 3, 4 Mustafa CENGİZ , Adnan AYHANCI , Hatice Mehtap KUTLU *, Ahmet MUSMUL 1 Department of Elementary Education, Siirt University, Siirt, Turkey 2 Department of Biology, Faculty of Arts and Science, Eskişehir Osmangazi University, Eskişehir, Turkey 3 Department of Biology, Faculty of Science, Anadolu University, Eskişehir, Turkey 4 Department of Biostatistics, Faculty of School Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey Received: Accepted/Published Online: Final Version: Abstract: Silymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this substance is poorly solved in water and tends to decompose in the intestine, its bioavailability decreasing before it can show real effect. With these limitations in mind, the present study aims to enhance the poor bioavailability of Sm by forming Sm-loaded solid lipid nanoparticles (Sm-SLNs) using the hot homogenization method. A characterization process was undertaken to determine possible impact of Sm on experimental kidney damage. Our biochemical and light microscopic results suggest that the group that received Sm-SLNs for the treatment of D-GalN/ TNF-α–induced experimental kidney damage showed significantly more improvement than the group that received commercially available Sm. In conclusion, Sm-loaded SLN may be a useful system for the delivery of poorly water-soluble Sm and may also provide renoprotection. Key words: D-GalN/TNF-α, kidney damage, silymarin, solid lipid .

• Sinh học
• Kidney damage
• Solid lipid nanoparticle
• Anticarcinogenic propertie
• Sm loaded solid lipid nanoparticles
• Renal dysfunction
• BMC Cancer
• Cell cycle
• DNA damage
• Kidney cancer
• Kidney development
• Renal cell carcinoma
• Hypertensive nephropathy
• Renin angiotensin system
• Dihydroflavone family
• Angiotensin converting enzyme
• Hypertensive kidney damage
• trình bày báo cáo
• tài liệu báo cáo khoa học
• báo cáo bệnh thú y
• kiến thức bênh thú y
• nghiên cứu bệnh thú y
• Journal of Biology
• Cisplatin induced nephrotoxicity
• First line anticancer agent
• Potential reno protective substances
• Oxygen carrying capacity
• Oxidative stress index (OSI)
• BMC Veterinary Research
• BCL2 genes
• Reduced glutathione
• Glutathione peroxidase
• Lipid profile
• Wistar rat
• Experimentally induced renal dysfunction
• Niacin supplementation
• Heart failure patients
• Estimated glomerular filtration rate
• Relationship renal function
• The degree of HF
• Hepatic arterial infusion chemotherapy
• Hepatic vein tumor thrombosis
• Hepatocellular carcinoma
• Liver resection
• Veno venous bypass
• Heart failure
• Left ventricular ejection fraction
• Serum BNP
• BMC Anesthesiology
• Renal adjustment dose
• Augmented renal clearance
• Serum concentration
• Kidney dysfunction
• Living donor kidney transplantation
• End stage renal disease
• Diastolic dysfunction
• Pulmonary edema
• Tissue Doppler imaging
• Immunological and Molecular
• Renal Myofibroblasts
• Maternal Renal Dysfunction
• Proteomic Biomarkers
• Early Detection
• Acute Kidney Injury
• Feeding Influences
• Weight of Children
• Breastfeeding Reduce
• Risk Factors
• Dialysis Disequilibrium Syndrome
• Nitrosative Stress
• Molecular Mechanisms
• mmunologica