TAILIEUCHUNG - The antioxidant and DNA protection potential of Indian tribal medicinal plants

Prevention and treatment of various degenerative diseases using traditional medicines is increasingly generating interest, especially in geriatric clinical research. This study aimed to evaluate the free-radical scavenging properties and potential to prevent DNA damage (from oxidative stress) of 56 extracts (polar and non-polar) from 14 medicinal plants (from 12 families) used by diverse Indian tribes and ethnic groups. | Turk J Biol 35 (2011) 233-242 © TÜBİTAK doi: The antioxidant and DNA protection potential of Indian tribal medicinal plants Gunjan GUHA, Venkatadri RAJKUMAR, Lazar MATHEW, R. Ashok KUMAR Division of Biomedical Sciences, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu - INDIA Received: Abstract: Prevention and treatment of various degenerative diseases using traditional medicines is increasingly generating interest, especially in geriatric clinical research. This study aimed to evaluate the free-radical scavenging properties and potential to prevent DNA damage (from oxidative stress) of 56 extracts (polar and non-polar) from 14 medicinal plants (from 12 families) used by diverse Indian tribes and ethnic groups. Although widely known for traditional uses, these G plants have not been extensively used for clinical purposes. Scavenging of DPPH radical by all the extracts was evaluated to estimate their antioxidant potential and rank them accordingly. Extracts occupying the top 10 ranks were further G+ +3 evaluated and extensively screened for their antioxidant potential by estimation of their ABTS -scavenging and Fe reducing properties. A cumulative ranking system was designed for these 10 plant extracts based on the results of the 3 antioxidant assays. Simultaneously, protection of DNA against photolyzed H2O2-induced oxidative damage by all 56 extracts was studied in pBR322. Considerable anti-genotoxic potential was exhibited by the top 3 extracts on the cumulative rank table, thereby proving the results of all the experiments were congruent. This is a preliminary report, which may yield a roadmap for isolating the active components from these extracts and designing geriatric medicines. Key words: Tribal medicinal plants, antioxidant, oxidative damage, DNA protection, DPPH, ABTS Hint kabilelerinin tıbbi bitkilerin DNA koruma ve antioksidan potansiyeli Özet: Geleneksel ilaçların kullanımı ile çeşitli .

• Sinh học
• Tribal medicinal plants
• Oxidative damage
• DNA protection
• Butylated hydroxyanisole
• Oxidative stress
• Ethno medicinal plants
• Apiaceae and fabaceae
• Tribal communities
• Traditional health practices of rural
• Traditional health practices
• Snake bite remedies
• Medicinal plants
• Digital documentation
• Irula tribes
• Herbal snake bite remedies
• Haematobiochemical and oxidative stress
• Dogs affected with gastroenteritis
• Haemato biochemical
• Oxidative stress parameters
• Heat stress
• Tropical climate
• Oxidative stress markers
• Blood plasma of Tharparkar
• Mesenchymal stem cells
• Oxidative stress plays
• Anti inflammatory
• Human mesenchymal stem cells
• IL8RB gene polymorphism
• Potential immunocompromised adherent
• Exaggeration of parenteral
• Mammo crine oxidative stress
• During mastitis in buffalo
• Uterine fluid scoring
• Somatic cell count
• Oxidative stress on occurrence
• Subclinical mastitis
• Dairy cattle
• Bovine mastitis related oxidative stress
• Therapeutic regimen
• Multi etiological complex disease
• Oxidative stress biomarkers
• Biomarkers in horses
• Stud farm located
• Female horses having same age group
• Assessment of oxidative stress
• Trace elements in pregnant Kankrej cows
• Pregnant Kankrej cows
• Pregnant Kankrej cow
• Vitamin C moderates
• Oxidative stress of bubaline pediculosis
• Indian water buffaloes
• N acetyl cysteine
• Sucking lice
• Biotechnology and food sciences
• Basella alba linn modulates acrylamide
• Wistar rats
• Basella alba
• BMC Veterinary Research
• Heart failure
• Echocardiographic changes
• Heart ischemia
• Heart infarction
• Cardiomyocyte remains unclear
• Antisense based therapies
• Hypoxia induced oxidative stress
• Journal of Botany
• Cladophora glomerata
• Cadmium induced oxidative stress
• Biochemical response
• Metal induced oxidative stress
• Public health
• Metabolic stress
• Health space
• Multiple biomarkers
• Oxidative stress mediated dose dependent
• Cadmium chloride
• Subacute toxicity
• Male rats
• Ocimum gratissimum
• Schwann cells
• Anti oxidative properties
• Folk medicine
• BMC Bioinformatics
• Structural systems biology
• Structural proteome
• Physicochemical properties
• Metabolic model
• BMC Molecular and Cell Biology
• Podocyte plays
• Glomerular filtration barrier
• Forkhead transcription factor
• Anti oxidative signaling
• Ebook Studies on renal disorders
• Studies on renal disorders
• Transition metals
• Clinical aspects of oxidative stress
• Current therapy targeting oxidative tress
• Lead stress
• Antioxidant enzymes
• DNA mutations
• β estradiol
• BMC Plant Biology
• Combined overexpression
• Drastic oxidative stress
• Enhanced seed longevity
• Heat Shock Factors
• Severe dehydration
• Stress tolerance
• BMC Genomics
• Aspergillus fumigatus
• Combinatorial stress
• Iron deprivation
• Scientific reports
• scientific research
• Structural biochemistry
• transgenic mice
• genetics
• biochemistry
• molecular Biology
• defense responses
• Structural Biology
• breast cancer
• medicine
• mitochondrial
• chemical reaction