TAILIEUCHUNG - Study on the synthesis of some new Derivatives of malloapelta B isolated from Mallotus apelta

Six new benzopyran derivatives were synthesized by reduction reaction and Michael reaction from malloapelta B. Their structures were determined as 8-(1’-oxo-butyl)-5,7-dimethoxy-2,2- dimethyl-2H-1-benzopyran (2), 8-(1’-oxo-3’(R)-methyl-4’-acetyl-5’-oxo-hexyl)-5,7-dimethoxy- 2,2-dimethyl-2H-1-benzopyran (3), 8-(1’-oxo-3’(R)-methyl-4’(S/R)-(methyl fomiate)-5’-oxohexyl)-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (4,4’), 8-(1’-oxo-3’(R)-methyl-4’(S/R)-(ethyl formiate)-5’-oxo-hexyl)-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (5,5’) by spectroscopic data, including two-dimensional NMR techniques and ESI spectrum. | Journal of Chemistry Vol. 45 2 P. 250 - 254 2007 STUDY ON THE SYNTHESIS OF SOME NEW DERIVATIVES OF MALLOAPELTA B ISOLATED FROM MALLOTUS APELTA Received 6 June 2006 NGUyEN HQAI NAM NGUyEN Huu TUNG NGUyEN XUAN NHIEM CHAU VAN MINH PHAN VAN KIEM Institute of Natural Products Chemistry Vietnamese Academy of Science and Technology SUMMARy Six new benzopyran derivatives were synthesized by reduction reaction and Michael reaction from malloapelta B. Their structures were determined as 8- -5 2-dimethyl-2H-1 -benzopyran 2 8- 1 -oxo-3 R -methyl-4 -acetyl-5 -oxo-hexyl -5 7-dimethoxy-2 2-dimethyl-2H-1-benzopyran 3 8- 1 -oxo-3 R -methyl-4 S R - methyl fomiate -5 -oxo-hexyl -5 7-dimethoxy-2 2-dimethyl-2H-1 -benzopyran 4 4J 8- r-oxo-3 R -methyl-V S R - ethyl formiate -5 -oxo-hexyl -5 7-dimethoxy-2 2-dimethyl-2H-1-benzopyran 5 5 by spectroscopic data including two-dimensional NMR techniques and ESI spectrum. Keywords Malloapelta B Michael reaction reduction reaction 5 7-dimethoxy-2 2-dimethyl-2H-1-benzopyran. I - INTRODUCTION Malloapelta B 1 a new benzopyran derivative was isolated from the Vietnamese traditional medicinal plant Mallotus apelta Lour. . 1 . It shows strong cytotoxic effect as well as strong activity against NF-kB activation with IC50 value pM. This compound is continued studying further for cancer treatment 2 3 . To investigate the relations between the structures and their bioactivities as well as probably find new derivatives having stronger bioactivities we have synthesized a series of its derivatives. As a part of our research we report herein six new derivatives synthesized by reduction reaction and Michael reaction. Their structures were determined as 8- 1 -oxo-butyl -5 7-dimethoxy-2 2-dimethyl-2H-1-benzopyran 2 8- 1 -oxo-3 R -methyl-4 -acetyl-5 -oxo-hexyl -5 7-dimethoxy-2 2-dimethyl-2H-1-benZopyran 3 8- 1 -oxo-3 R -methyl-4 S R -250 methyl formiate -5 -oxo-hexyl -5 7-dimethoxy -2 2-dimethyl-2H-1-benzopyran 4 4 .

• Hoá học
• Công nghệ hóa
• Malloapelta B
• Michael reaction
• Reduction reaction
• Chất dẫn xuất
• Phản ứng khử
• Kỹ thuật hệ thống công nghệ hóa học
• Hệ thống công nghệ hóa học
• Công nghệ hóa học
• Tối ưu hóa
• Quá trình công nghệ hóa học
• Phương pháp giải thích
• Quy hoạch toán học
• Phương pháp gradient
• Mô hình hóa công nghệ hóa học
• Nghiên cứu công nghệ hóa học
• Mô tả công nghệ hóa học
• giáo trình công nghệ hóa học
• thiết bị công nghệ hóa học
• bài giảng công nghệ hóa học
• công nghệ hóa chất
• tài liệu công nghệ hóa chất
• áp dụng công nghệ hóa chất
• tìm hiểu công nghệ hóa chất
• nghiên cứu công nghệ hóa chất
• công nghệ hóa dầu
• bài giảng công nghệ hóa dầu
• giáo trình công nghệ hóa dầu
• tài liệu công nghệ hóa dầu
• lý thuyết công nghệ hóa dầu