TAILIEUCHUNG - Báo cáo khoa học: Multiple enzymic activities of human milk lactoferrin

Lactoferrin (LF) is a Fe 3+ -binding glycoprotein, first recognized in milk and then in other human epithelial secretions and barrier fluids. Many different functions have been attributed to LF, including protection from iron-induced lipid peroxidation, immunomodulation and cell growthregulation, DNA binding, and transcriptional acti-vation. Its physiological role is still unclear, but it has been suggested to be responsible for primary defense against microbial and viral infection. | Eur. J. Biochem. 270 3353-3361 2003 FEBS 2003 doi Multiple enzymic activities of human milk lactoferrin Tat yana G. Kanyshkova1 Svetlana E. Babina2 Dmitry V. Semenov1 Natal ya Isaeva3 Alexander V. Vlassov1 Kirill N. Neustroev4 Anna A. Kul minskaya4 Valentina N. Buneva1 and Georgy A. Nevinsky1 1Novosibirsk Institute of Bioorganic Chemistry Siberian Division of Russian Academy of Sciences Novosibirsk Russia Novosibirsk State University Novosibirsk Russia 3Institute of Cytology and Genetics Siberian Division of the Russian Academy of Sciences Novosibirsk Russia 4Petersburg Nuclear Physics Institute of Russian Academy of Sciences St Peterburg Russia Lactoferrin LF is a Fe3 -binding glycoprotein first recognized in milk and then in other human epithelial secretions and barrier fluids. Many different functions have been attributed to LF including protection from iron-induced lipid peroxidation immunomodulation and cell growth rggulaiion. DNA binding and inmcripiiKUKll activation. Its physiological role is still unclear but it has been suggested to be responsible for primary defense against microbial and viral infection. We present evidence that different subfractions of purified human milk LF possess five different enzyme activities DNase RNase ATPase phosphatase and malto-oligosaccharide hydrolysis. LF is the predominant source of these activities in human milk. Some of its catalytically active subfractions are cytotoxic and induce apoptosis. The discovery that LF possesses these activities may help to elucidate its many physiological functions including its protective role against microbial and viral infection. Keywords enzymic activities human milk lactoferrin protection. Lactoferrin LF is a single polypeptide chain of 76-80 kDa containing two lobes 1 each of which hinds one Fe3 ion and contains one glycan chain 2 . It was first recognized in milk and then in other human epithelial secretions and barrier body fluids 3-6 . Many .

• Báo cáo khoa học
• scientific reports
• Report medicine
• traditional medicine
• oxidation
• chemical reaction
• tumor cells
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• scientific research
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes