TAILIEUCHUNG - Báo cáo "A new 3α-acetoxy-urs-23,28,30-trioic acid from the leaves of Acanthopanax Trifoliatus "

A new 3 -acetoxy-urs-23,28,30-trioic acid, named acantrifoic acid B (1), has been isolated from the leaves of Acanthopanax trifoliatus. Its chemical structure has been characterized on the basis of spectral and chemical evidence. I - INTRODUCTION Acanthopanax trifoliatus (L.) Merr., (Araliaceae) is distributed in North Vietnam and used in the folk medicines of south–east Asia (Chi, 1997; Loi, 2001) as a drug with ginsenglike activity. Lupane-triterpene carboxylic acids and a lupane-triterpene glycoside have been reported from the leaves of A. trifoliatus (Ty et al., 1984; Lischewski et al., 1985; Yook et al., 1998). As a part of our continuing studies. | Journal of Chemistry Vol. 42 1 P. 121 -124 2004 A NEW 3a-ACETOXy-URS-23 28 30-TRIOIC ACID FROM THE lEAVES OF ACANTHOPANAX TRIFOLIATUS Received 7-7-2003 PHAN VAN KIEM1 NGUyEN HEN DAT3 CHAU VAN MINH1 JUNG JOON LEE2 YOUNG HO KIM3 institute of Natural Products Chemistry Vietnamese Academy of Science and Technology 2Korea Research Institute of Bioscience and Biotechnology Daejeon Korea 3College of Pharmacy Chungnam National University Daejeon Korea ABSTRACT A new 3a-acetoxy-urs-23 28 30-trioic acid named acantrifoic acid B 1 has been isolated from the leaves of Acanthopanax trifoliatus. Its chemical structure has been characterized on the basis of spectral and chemical evidence. I - INTRODUCTION Acanthopanax trifoliatus L. Merr. Araliaceae is distributed in North Vietnam and used in the folk medicines of south-east Asia Chi 1997 Loi 2001 as a drug with ginsenglike activity. Lupane-triterpene carboxylic acids and a lupane-triterpene glycoside have been reported from the leaves of A. trifoliatus Ty et al. 1984 Lischewski et al. 1985 Yook et al. 1998 . As a part of our continuing studies on Acanthopanax species we report here the isolation and the structure determination of a new compound from A. trifoliatus. Based on spectroscopic data the chemical structure of constituent was determined as 3a-acetoxy-urs-23 28 30-trioic acid 1 . II - RESULTS AND DISCUSSION Repeated column chromatography on silica gel of the dichloromethane extract of the dried leaves of A. trifoliatus yielded a new carboxylic acid 1. Compound 1 was formed as white crystals and produced a due to carbonyl IR absorption peaks at 1748 - 1750 cm-1 acid IR absorption peaks at 3400 cm-1. The FAB-MS spectrum of 1 showed an M H ion peak at m z 561 correspond to a molecular formula of C32H48O8. The 1H-NMR spectrum of 1 Table 1 showed signals due to five tertiary methyl groups Ô 3H s H3-25 3H s H3-26 30 COOH 3H d J Hz H3-29 3H s H3-27 and 3H s H3-24 one oxygen bearing a proton Ỗ .

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