TAILIEUCHUNG - Báo cáo khoa học: S-Layers as a basic building block in a molecular construction kit

Crystalline arrays of protein or glycoprotein subunits forming surface layers (S-layers) are the most common outermost envelope components of prokaryotic organisms (archaea and bacteria). The wealth of information on the structure, chemistry, genetics, morphogenesis, and function of S-layers has revealed a broad application potential. | ỊFEBS Journal MINIREVIEW S-Layers as a basic building block in a molecular construction kit Uwe B. Sleytr Eva M. Egelseer Nicola Ilk Dietmar Pum and Bernhard Schuster Center for NanoBiotechnology University of NaturalResources and Applied Life Sciences Vienna Austria Keywords biomimetics biosensors nanobiotechnology nanoparticles S-layers Correspondence U. B. Sleytr Center for NanoBiotechnology University of NaturalResources and Applied Life Science Vienna Gregor-Mendel-Strasse 33 1180 Vienna Austria Fax 43 1 4789112 Tel 43 1 47654 2201 E-mail This paper is dedicated to the memory of Margit Sara Crystalline arrays of protein or glycoprotein subunits forming surface layers S-layers are the most common outermost envelope components of prokaryotic organisms archaea and bacteria . The wealth of information on the structure chemistry genetics morphogenesis and function of S-layers has revealed a broad application potential. As S-layers are periodic structures they exhibit identical physicochemical properties for each molecular unit down to the subnanometer level and possess pores of identical size and morphology. Many applications of S-layers in nanobiotechnology depend on the ability of isolated subunits to recrystallize into monomolecular lattices in suspension or on suitable surfaces and interfaces. S-Layer lattices can be exploited as scaffolding and patterning elements for generating more complex supramolecular assemblies and structures as required for life and nonlife science applications. Received 6 October 2006 accepted 14 November 2006 doi Introduction Methods for organizing materials at the nanometer level are essential for the fabrication of supramolecular structures and devices. Thus molecular self-assembly systems that exploit the molecular scale manufacturing precision of biological systems are prime candidates in nanobiotechnology. Crystalline bacterial cell surface layer S-layer proteins have been .

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