TAILIEUCHUNG - Báo cáo khoa học: The double-stranded RNA-binding motif, a versatile macromolecular docking platform

The double-stranded RNA-binding motif (dsRBM) is anabbbafold with a well-characterized function to bind structured RNA molecules. This motif is widely distributed in eukaryotic proteins, as well as in proteins from bac-teria and viruses. dsRBM-containing proteins are involved in processes ran-ging from RNA editing to protein phosphorylation in translational control and contain a variable number of dsRBM domains. | ềFEBS Journal MINIREVIEW The double-stranded RNA-binding motif a versatile macromolecular docking platform Kung-Yao Chang1 and Andres Ramos2 1 Institute of Biochemistry NationalChung-Hsing University Taichung Taiwan 2 Molecular Structure Division NationalInstitute for MedicalResearch Mill Hill London UK Keywords dsRBD function dsRBM-RNA interaction dsRBM-protein interaction multidomain proteins Correspondence . Chang Institute of Biochemistry NationalChung-Hsing University 250 Kuo-Kung Road Taichung 402 Taiwan E-mail kychang@ A. Ramos Molecular Structure Division National Institute for Medical Research The Ridgeway Mill Hill London NW7 1AA UK E-mail aramos@ Received 15 December 2004 accepted 7 March 2005 doi The double-stranded RNA-binding motif dsRBM is an ppp fold with a well-characterized function to bind structured RNA molecules. This motif is widely distributed in eukaryotic proteins as well as in proteins from bacteria and viruses. dsRBM-containing proteins are involved in processes ranging from RNA editing to protein phosphorylation in translational control and contain a variable number of dsRBM domains. The structural work of the past five years has identified a common mode of RNA target recognition by dsRBMs and dissected this recognition into two functionally separated interaction modes. The first involves the recognition of specific moieties of the RNA A-form helix by two protein loops while the second is based on the interaction between structural elements flanking the RNA duplex with the first helix of the dsRBM. The latter interaction can be tuned by other protein elements. Recent work has made clear that dsRBMs can also recognize non-RNA targets proteins and DNA and act in combination with other dsRBMs and non-dsRBM motifs to play a regulatory role in catalytic processes. The elucidation of functional networks coordinated by dsRBM folds will require information on the precise .

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