TAILIEUCHUNG - Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism

Methionine (Met) is an essential amino acid and the only sub-strate for synthesis of S-adenosylmethionine (AdoMet) that is the main substrate for multiple intracellular methylases. There are two modes of Met metabolism in liver. In case of its dietary restriction Met can be metabolized via conservative remethylation cycle. In case of Met excess (high [Met]) it is mostly converted to cysteine via transsulfuration pathway. | Abstracts Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism T. K. Korendyaseva V. A. Volkov D. N. Kuvatov M. V. Martinov V. M. Vitvitsky and F. I. Ataullakhanov Laboratory of Physical Biochemistry National Research Center for Hematology Moscow Russia. E-mail ruah@ Methionine Met is an essential amino acid and the only substrate for synthesis of S-adenosylmethionine AdoMet that is the main substrate for multiple intracellular methylases. There are two modes of Met metabolism in liver. In case of its dietary restriction Met can be metabolized via conservative remethylation cycle. In case of Met excess high Met it is mostly converted to cysteine via transsulfuration pathway. Mathematical modeling of methionine metabolism in liver Martinov et al. 2000 predicts that transition from Met conservation to Met consumption happens in narrow Met range and is accompanied by sharp 10-fold increase in AdoMet and by significant increase in the rate of Met consumption. To test model predictions we analyzed the dependence of AdoMet and the rate of Met consumption on Met in suspension of freshly isolated mouse hepatocytes. Met varied from 40 to 400 iM. In the narrow Met range from 80 to 120 iM AdoMet sharply increased by eight times while Met consumption rate increased by six times in Met range from 40 to 150 iM. This data confirms the existence of the metabolic switch in liver metabolism triggered by Met concentration. PP-2 Effects of hyperthermia on mitochondrial respiration and NAD P H fluorescence R. Zukiene1 P. Cizas1 S. Maslauskaite1 R. Baniene2 and V. Mildaziene1 1Department of Biology Vytautas Magnus University Kaunas Lithuania 2Institute for Biomedical Research University of Medicine Kaunas Lithuania. E-mail Hyperthermia has high potential as a cancer treatment modality. That implies the need to determine the kinetic response of mitochondria from healthy tissue to moderate heating as .

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