TAILIEUCHUNG - Báo cáo khoa học: A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis

Glutaredoxins (Grxs) have been shown to be critical in maintaining redox homeostasis in living cells. Recently, an emerging subgroup of Grxs with one cysteine residue in the putative active motif (monothiol Grxs) has been identified. | 1FEBS Journal A mammalian monothiol glutaredoxin Grx3 is critical for cell cycle progression during embryogenesis Ning-Hui Cheng1 2 Wei Zhang3 Wei-Qin Chen4 Jianping Jin5 Xiaojiang Cui6 Nancy F. Butte1 2 Lawrence Chan4 and Kendal D. Hirschi1 2 1 United States Department of Agriculture AgriculturalResearch Service Children s Nutrition Research Center Baylor College of Medicine Houston TX USA 2 Department of Pediatrics Baylor College of Medicine Houston TX USA 3 Molecular Physiology and Biophysics Baylor College of Medicine Houston TX USA 4 Molecular and Cellular Biology Baylor College of Medicine Houston TX USA 5 Department of Biochemistry and Molecular Biology The University of Texas Health Science Center at Houston Houston TX USA 6 Department of Molecular Oncology John Wayne Cancer Institute Santa Monica CA USA Keywords cell cycle embryogenesis glutaredoxin mouse oxidative stress Correspondence . Cheng United States Department of Agriculture AgriculturalResearch Service Children s Nutrition Research Center Department of Pediatrics Baylor College of Medicine Houston TX 77030 USA Fax 1 713 798 7101 Tel 1 713 798 9326 E-mail ncheng@ Lawrence Chan and KendalD. Hirschi contributed equally to this work Received 1 February 2011 revised 8 April 2011 accepted 11 May 2011 doi Glutaredoxins Grxs have been shown to be critical in maintaining redox homeostasis in living cells. Recently an emerging subgroup of Grxs with one cysteine residue in the putative active motif monothiol Grxs has been identified. However the biological and physiological functions of this group of proteins have not been well characterized. Here we characterize a mammalian monothiol Grx Grx3 also termed TXNL2 PICOT with high similarity to yeast ScGrx3 ScGrx4. In yeast expression assays mammalian Grx3s were localized to the nuclei and able to rescue growth defects of grx3grx4 cells. Furthermore Grx3 inhibited iron accumulation in yeast grx3gxr4 cells and .

• Báo cáo khoa học
• Scientific reports
• molecular Biology
• genetics
• embryonic cells
• mammals
• scientific research
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes