TAILIEUCHUNG - Báo cáo khoa học: Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds

Synthetic organic selenium compounds such as 2-phenyl-1,2-benziso-selenazol-3(2H)-one may show glutathione peroxidase-like antioxidant activity. Recently, we synthesized new organic selenium compounds that are thought to be effective antioxidants. | ễFEBS Journal Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds Hiroyuki Tsukagoshi1 Mamoru Koketsu2 Masahiko Kato1 Masahiko Kurabayashi3 Atsuyoshi Nishina4 and Hirokazu Kimura5 1 Gunma PrefecturalInstitute of Public Health and EnvironmentalSciences Maebashi Japan 2 Division of InstrumentalAnalysis Life Science Research Center Gifu University Japan 3 Department of Medicine and BiologicalScience Gunma University Graduate Schoolof Medicine Maebashi Japan 4 Gunma IndustrialTechnology Center Maebashi Japan 5 Infectious Disease Surveillance Center NationalInstitute of Infectious Diseases Tokyo Japan Keywords antioxidant O2- scavenger selenium selenourea tertiary selenoamide Correspondence H. Kimura Infectious Disease Surveillance Center NationalInstitute of Infectious Diseases 4-7-1 Gakuen Musashimurayama Tokyo 208-0011 Japan Fax 81 42 565 3315 Tel 81 42 561 0771 E-mail kimhiro@ Received 2 August 2007 revised 1 October 2007 accepted 3 October 2007 doi Synthetic organic selenium compounds such as 2-phenyl-1 2-benziso-selenazol-3 2H -one may show glutathione peroxidase-like antioxidant activity. Recently we synthesized new organic selenium compounds that are thought to be effective antioxidants. To study their possible applications as antioxidants we evaluated two selenoureas N N-dimethylselenourea and 1-selenocarbamoylpyrrolidine and two tertiary selenoamides N- phenylsele-nocarbonyl -piperidine and N N-diethyl-4-chloroselenobenzamide for their superoxide radical O2- -scavenging effects and toxicity. We measured O2--scavenging effects in polymorphonuclear leukocytes PMNs with a specific sensitive and real-time kinetic chemiluminescence method. Furthermore the toxicity of these compounds was measured in some human cell lines and PMNs using the tetrazolium method. Hydrogen peroxide was measured by a scopoletin method. Finally .

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