TAILIEUCHUNG - Báo cáo sinh học: "Reconstructing protein structure from solvent exposure using tabu search"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: Reconstructing protein structure from solvent exposure using tabu search. | Algorithms for Molecular Biology BioMed Central Research Reconstructing protein structure from solvent exposure using tabu search Martin Paluszewski 1 Thomas Hamelryck2 and Pawel Winter1 Open Access Address Department of Computer Science University of Copenhagen Universitetsparken 1 2100 Copenhagen Denmark and 2Bioinformatics Center Institute of Molecular Biology University of Copenhagen Universitetsparken 15 building 10 2100 Copenhagen Denmark Email Martin Paluszewski - palu@ Thomas Hamelryck - thamelry@ Pawel Winter - pawel@ Corresponding author Published 27 October 2006 Received 30 March 2006 Algorithms for Molecular Biology 2006 1 20 doi 1748-7188-1 -20 Accepted 27 October 2006 This article is available from http content 1 1 20 2006 Paluszewski et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background A new promising solvent exposure measure called half-sphere-exposure HSE has recently been proposed. Here we study the reconstruction of a protein s Ca trace solely from structure-derived HSE information. This problem is of relevance for de novo structure prediction using predicted HSE measure. For comparison we also consider the well-established contact number CN measure. We define energy functions based on the HSE- or CN-vectors and minimize them using two conformational search heuristics Monte Carlo simulation MCS and tabu search TS . While MCS has been the dominant conformational search heuristic in literature TS has been applied only a few times. To discretize the conformational space we use lattice models with various complexity. Results The proposed TS heuristic with a .

• Báo cáo khoa học
• Báo cáo sinh học hay
• cách trình bày báo cáo
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học